Matches in SemOpenAlex for { <https://semopenalex.org/work/W200414466> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W200414466 endingPage "61" @default.
- W200414466 startingPage "1055" @default.
- W200414466 abstract "Intravitreal drug administration is the treatment of choice for bacterial endophtalmitis, but improved knowledge of vitreal pharmacokinetics is essential for the development of optimal antibiotic regimes. We used our recently developed sampling device to estimate vitreal gentamicin concentrations for up to 30 hr after an intravitreal bolus injection of gentamicin. The device is based on the principle of dialysis, whereby a constant flow rate of dialysate through a loop of dialysis fiber in the vitreous attains a gentamicin concentration proportional to the intravitreal gentamicin level around the fiber. The dialysate is continuously recovered and the collected samples then assayed for gentamicin. Normal cat eyes and those with induced bacterial endophthalmitis formed the two groups tested. Concentration-time data fitted well to an open single compartment pharmacokinetic model that incorporated the processes of transfer of drug from the injection site to the sampling site (a function of diffusion within the vitreous), and the elimination from the sampling site (a function of elimination from the vitreous). The initial phase of transfer between the injection and sampling site was rapid and rates were comparable in the two groups. Elimination rate constants were uniformly greater in infected eyes than in controls (0.107 hr-1 compared to 0.055 hr-1). Aqueous humor gentamicin concentrations in control eyes varied between 3 and 6 times those found in fellow infected eyes at the end of each experiment. Accelerated elimination of gentamicin from the vitreous body of eyes with endophthalmitis may be explained by increased permeability of the blood-retinal barrier." @default.
- W200414466 created "2016-06-24" @default.
- W200414466 creator A5015360109 @default.
- W200414466 creator A5032946705 @default.
- W200414466 creator A5046421294 @default.
- W200414466 creator A5072735722 @default.
- W200414466 creator A5086940983 @default.
- W200414466 date "1989-06-01" @default.
- W200414466 modified "2023-09-23" @default.
- W200414466 title "Pharmacokinetics of intravitreal injection. Assessment of a gentamicin model by ocular dialysis." @default.
- W200414466 cites W1588850020 @default.
- W200414466 cites W174172419 @default.
- W200414466 cites W189844474 @default.
- W200414466 cites W196899653 @default.
- W200414466 cites W1972599772 @default.
- W200414466 cites W1974740135 @default.
- W200414466 cites W1993823564 @default.
- W200414466 cites W1998506847 @default.
- W200414466 cites W1998968802 @default.
- W200414466 cites W2002033083 @default.
- W200414466 cites W2010628499 @default.
- W200414466 cites W2019942756 @default.
- W200414466 cites W2020847657 @default.
- W200414466 cites W2029892497 @default.
- W200414466 cites W2052929273 @default.
- W200414466 cites W2071998382 @default.
- W200414466 cites W2082669071 @default.
- W200414466 cites W2126968506 @default.
- W200414466 cites W2141171349 @default.
- W200414466 cites W39426453 @default.
- W200414466 cites W80989238 @default.
- W200414466 cites W2109358013 @default.
- W200414466 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2786512" @default.
- W200414466 hasPublicationYear "1989" @default.
- W200414466 type Work @default.
- W200414466 sameAs 200414466 @default.
- W200414466 citedByCount "12" @default.
- W200414466 crossrefType "journal-article" @default.
- W200414466 hasAuthorship W200414466A5015360109 @default.
- W200414466 hasAuthorship W200414466A5032946705 @default.
- W200414466 hasAuthorship W200414466A5046421294 @default.
- W200414466 hasAuthorship W200414466A5072735722 @default.
- W200414466 hasAuthorship W200414466A5086940983 @default.
- W200414466 hasConcept C112705442 @default.
- W200414466 hasConcept C139254425 @default.
- W200414466 hasConcept C141071460 @default.
- W200414466 hasConcept C185592680 @default.
- W200414466 hasConcept C192670549 @default.
- W200414466 hasConcept C2775832221 @default.
- W200414466 hasConcept C2777235844 @default.
- W200414466 hasConcept C2777787772 @default.
- W200414466 hasConcept C42219234 @default.
- W200414466 hasConcept C43376680 @default.
- W200414466 hasConcept C501593827 @default.
- W200414466 hasConcept C55493867 @default.
- W200414466 hasConcept C71924100 @default.
- W200414466 hasConcept C98274493 @default.
- W200414466 hasConceptScore W200414466C112705442 @default.
- W200414466 hasConceptScore W200414466C139254425 @default.
- W200414466 hasConceptScore W200414466C141071460 @default.
- W200414466 hasConceptScore W200414466C185592680 @default.
- W200414466 hasConceptScore W200414466C192670549 @default.
- W200414466 hasConceptScore W200414466C2775832221 @default.
- W200414466 hasConceptScore W200414466C2777235844 @default.
- W200414466 hasConceptScore W200414466C2777787772 @default.
- W200414466 hasConceptScore W200414466C42219234 @default.
- W200414466 hasConceptScore W200414466C43376680 @default.
- W200414466 hasConceptScore W200414466C501593827 @default.
- W200414466 hasConceptScore W200414466C55493867 @default.
- W200414466 hasConceptScore W200414466C71924100 @default.
- W200414466 hasConceptScore W200414466C98274493 @default.
- W200414466 hasIssue "6" @default.
- W200414466 hasLocation W2004144661 @default.
- W200414466 hasOpenAccess W200414466 @default.
- W200414466 hasPrimaryLocation W2004144661 @default.
- W200414466 hasRelatedWork W2015095033 @default.
- W200414466 hasRelatedWork W2033096072 @default.
- W200414466 hasRelatedWork W2094502855 @default.
- W200414466 hasRelatedWork W2123504367 @default.
- W200414466 hasRelatedWork W2130782879 @default.
- W200414466 hasRelatedWork W2233451201 @default.
- W200414466 hasRelatedWork W2399105950 @default.
- W200414466 hasRelatedWork W2399580311 @default.
- W200414466 hasRelatedWork W2410011490 @default.
- W200414466 hasRelatedWork W2413244858 @default.
- W200414466 hasVolume "30" @default.
- W200414466 isParatext "false" @default.
- W200414466 isRetracted "false" @default.
- W200414466 magId "200414466" @default.
- W200414466 workType "article" @default.