Matches in SemOpenAlex for { <https://semopenalex.org/work/W2004151120> ?p ?o ?g. }
- W2004151120 endingPage "61" @default.
- W2004151120 startingPage "49" @default.
- W2004151120 abstract "The use of a temperature-shift to subphysiological temperatures (<37°C) during the culturing of mammalian cell lines engineered to produce a recombinant protein is widely utilized. The effect of such a temperature shift on both the cellular responses and recombinant protein yield is not uniform and is both cell- and product-specific. Despite this, the understanding of the cellular responses to mild subphysiological temperature (27–35°C) culturing has developed markedly over the last decade and, as such, opportunities exist to harness this knowledge to further improve product yields and quality at subphysiological temperatures. In this review we describe the mammalian cell response to mild subphysiological temperature, the effects on recombinant protein production under such conditions, those mechanisms that appear to underpin increases in productivity at such temperatures, and potential future innovations and directions that may further enhance the use of such conditions during bioprocessing of recombinan..." @default.
- W2004151120 created "2016-06-24" @default.
- W2004151120 creator A5008673050 @default.
- W2004151120 creator A5017406022 @default.
- W2004151120 date "2014-02-01" @default.
- W2004151120 modified "2023-10-05" @default.
- W2004151120 title "The impact of process temperature on mammalian cell lines and the implications for the production of recombinant proteins in CHO cells" @default.
- W2004151120 cites W1573796272 @default.
- W2004151120 cites W1967142377 @default.
- W2004151120 cites W1967681366 @default.
- W2004151120 cites W1972892361 @default.
- W2004151120 cites W1974887619 @default.
- W2004151120 cites W1976674039 @default.
- W2004151120 cites W1979668518 @default.
- W2004151120 cites W1980167726 @default.
- W2004151120 cites W1983650071 @default.
- W2004151120 cites W1985719186 @default.
- W2004151120 cites W1988041246 @default.
- W2004151120 cites W1996759600 @default.
- W2004151120 cites W2001919111 @default.
- W2004151120 cites W2007180791 @default.
- W2004151120 cites W2008907048 @default.
- W2004151120 cites W2009135449 @default.
- W2004151120 cites W2009191320 @default.
- W2004151120 cites W2010385141 @default.
- W2004151120 cites W2014010198 @default.
- W2004151120 cites W2018937130 @default.
- W2004151120 cites W2020066842 @default.
- W2004151120 cites W2022156041 @default.
- W2004151120 cites W2027783748 @default.
- W2004151120 cites W2029878671 @default.
- W2004151120 cites W2039395021 @default.
- W2004151120 cites W2044635032 @default.
- W2004151120 cites W2044925931 @default.
- W2004151120 cites W2048354832 @default.
- W2004151120 cites W2049728326 @default.
- W2004151120 cites W2050719916 @default.
- W2004151120 cites W2052262880 @default.
- W2004151120 cites W2054395562 @default.
- W2004151120 cites W2054664724 @default.
- W2004151120 cites W2054820526 @default.
- W2004151120 cites W2057709925 @default.
- W2004151120 cites W2065629778 @default.
- W2004151120 cites W2066639891 @default.
- W2004151120 cites W2067210466 @default.
- W2004151120 cites W2072448981 @default.
- W2004151120 cites W2076119693 @default.
- W2004151120 cites W2077924848 @default.
- W2004151120 cites W2079015277 @default.
- W2004151120 cites W2079334252 @default.
- W2004151120 cites W2083317317 @default.
- W2004151120 cites W2086254928 @default.
- W2004151120 cites W2087787890 @default.
- W2004151120 cites W2089782927 @default.
- W2004151120 cites W2090875609 @default.
- W2004151120 cites W2091239325 @default.
- W2004151120 cites W2094221317 @default.
- W2004151120 cites W2096048497 @default.
- W2004151120 cites W2096617772 @default.
- W2004151120 cites W2098682002 @default.
- W2004151120 cites W2099934038 @default.
- W2004151120 cites W2102799896 @default.
- W2004151120 cites W2104694760 @default.
- W2004151120 cites W2110154943 @default.
- W2004151120 cites W2111660101 @default.
- W2004151120 cites W2111891508 @default.
- W2004151120 cites W2117045376 @default.
- W2004151120 cites W2118461522 @default.
- W2004151120 cites W2118540273 @default.
- W2004151120 cites W2127582347 @default.
- W2004151120 cites W2127971600 @default.
- W2004151120 cites W2128571608 @default.
- W2004151120 cites W2128888434 @default.
- W2004151120 cites W2130274346 @default.
- W2004151120 cites W2137417976 @default.
- W2004151120 cites W2139433719 @default.
- W2004151120 cites W2139978091 @default.
- W2004151120 cites W2140463382 @default.
- W2004151120 cites W2154882802 @default.
- W2004151120 cites W2167331864 @default.
- W2004151120 cites W2170064307 @default.
- W2004151120 cites W2256672295 @default.
- W2004151120 cites W2326539204 @default.
- W2004151120 cites W4256060828 @default.
- W2004151120 doi "https://doi.org/10.4155/pbp.14.3" @default.
- W2004151120 hasPublicationYear "2014" @default.
- W2004151120 type Work @default.
- W2004151120 sameAs 2004151120 @default.
- W2004151120 citedByCount "22" @default.
- W2004151120 countsByYear W20041511202014 @default.
- W2004151120 countsByYear W20041511202016 @default.
- W2004151120 countsByYear W20041511202018 @default.
- W2004151120 countsByYear W20041511202019 @default.
- W2004151120 countsByYear W20041511202020 @default.
- W2004151120 countsByYear W20041511202021 @default.
- W2004151120 countsByYear W20041511202022 @default.
- W2004151120 countsByYear W20041511202023 @default.
- W2004151120 crossrefType "journal-article" @default.