FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2004156005> ?p ?o ?g. }

• W2004156005 endingPage "224" @default.
• W2004156005 startingPage "218" @default.
• W2004156005 abstract "Adipose-derived stem cells (ASCs) have been found adapted to a specific niche with low oxygen tension (hypoxia) in the body. As an important component of this niche, oxygen tension has been known to play a critical role in the maintenance of stem cell characteristics. However, the effect of O2 tension on their functional properties has not been well determined. In this study, we investigated the effects of O2 tension on ASCs stemness, differentiation and proliferation ability. Human ASCs were cultured under normoxia (21% O2) and hypoxia (2% O2). We found that hypoxia increased ASC stemness marker expression and proliferation rate without altering their morphology and surface markers. Low oxygen tension further enhances the chondrogenic differentiation ability, but reduces both adipogenic and osteogenic differentiation potential. These results might be correlated with the increased expression of HIF-1α under hypoxia. Taken together, we suggest that growing ASCs under 2% O2 tension may be important in expanding ASCs effectively while maintaining their functional properties for clinical therapy, particularly for the treatment of cartilage defects." @default.
• W2004156005 created "2016-06-24" @default.
• W2004156005 creator A5007359797 @default.
• W2004156005 creator A5025648831 @default.
• W2004156005 creator A5045455484 @default.
• W2004156005 creator A5054769615 @default.
• W2004156005 creator A5069775773 @default.
• W2004156005 creator A5075966105 @default.
• W2004156005 creator A5091031886 @default.
• W2004156005 date "2014-05-01" @default.
• W2004156005 modified "2023-10-07" @default.
• W2004156005 title "Impact of low oxygen tension on stemness, proliferation and differentiation potential of human adipose-derived stem cells" @default.
• W2004156005 cites W1502442150 @default.
• W2004156005 cites W1966536689 @default.
• W2004156005 cites W1967366984 @default.
• W2004156005 cites W1973541913 @default.
• W2004156005 cites W1977025595 @default.
• W2004156005 cites W1984255682 @default.
• W2004156005 cites W1988357840 @default.
• W2004156005 cites W1991346678 @default.
• W2004156005 cites W1994561234 @default.
• W2004156005 cites W2002310197 @default.
• W2004156005 cites W2011653215 @default.
• W2004156005 cites W2019963386 @default.
• W2004156005 cites W2020333453 @default.
• W2004156005 cites W2023060332 @default.
• W2004156005 cites W2025371271 @default.
• W2004156005 cites W2030674042 @default.
• W2004156005 cites W2033641981 @default.
• W2004156005 cites W2043814008 @default.
• W2004156005 cites W2048539785 @default.
• W2004156005 cites W2058992881 @default.
• W2004156005 cites W2070773381 @default.
• W2004156005 cites W2083838222 @default.
• W2004156005 cites W2084680820 @default.
• W2004156005 cites W2089530989 @default.
• W2004156005 cites W2091229702 @default.
• W2004156005 cites W2110234623 @default.
• W2004156005 cites W2131624895 @default.
• W2004156005 cites W2137714792 @default.
• W2004156005 cites W2152471534 @default.
• W2004156005 cites W2155243243 @default.
• W2004156005 cites W2166924989 @default.
• W2004156005 cites W2171630160 @default.
• W2004156005 cites W2171965603 @default.
• W2004156005 doi "https://doi.org/10.1016/j.bbrc.2014.04.096" @default.
• W2004156005 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24785372" @default.
• W2004156005 hasPublicationYear "2014" @default.
• W2004156005 type Work @default.
• W2004156005 sameAs 2004156005 @default.
• W2004156005 citedByCount "111" @default.
• W2004156005 countsByYear W20041560052014 @default.
• W2004156005 countsByYear W20041560052015 @default.
• W2004156005 countsByYear W20041560052016 @default.
• W2004156005 countsByYear W20041560052017 @default.
• W2004156005 countsByYear W20041560052018 @default.
• W2004156005 countsByYear W20041560052019 @default.
• W2004156005 countsByYear W20041560052020 @default.
• W2004156005 countsByYear W20041560052021 @default.
• W2004156005 countsByYear W20041560052022 @default.
• W2004156005 countsByYear W20041560052023 @default.
• W2004156005 crossrefType "journal-article" @default.
• W2004156005 hasAuthorship W2004156005A5007359797 @default.
• W2004156005 hasAuthorship W2004156005A5025648831 @default.
• W2004156005 hasAuthorship W2004156005A5045455484 @default.
• W2004156005 hasAuthorship W2004156005A5054769615 @default.
• W2004156005 hasAuthorship W2004156005A5069775773 @default.
• W2004156005 hasAuthorship W2004156005A5075966105 @default.
• W2004156005 hasAuthorship W2004156005A5091031886 @default.
• W2004156005 hasConcept C104317684 @default.
• W2004156005 hasConcept C122927707 @default.
• W2004156005 hasConcept C148738053 @default.
• W2004156005 hasConcept C171089720 @default.
• W2004156005 hasConcept C178790620 @default.
• W2004156005 hasConcept C185592680 @default.
• W2004156005 hasConcept C198826908 @default.
• W2004156005 hasConcept C28328180 @default.
• W2004156005 hasConcept C2993207723 @default.
• W2004156005 hasConcept C35496256 @default.
• W2004156005 hasConcept C540031477 @default.
• W2004156005 hasConcept C55493867 @default.
• W2004156005 hasConcept C7836513 @default.
• W2004156005 hasConcept C86803240 @default.
• W2004156005 hasConcept C95444343 @default.
• W2004156005 hasConceptScore W2004156005C104317684 @default.
• W2004156005 hasConceptScore W2004156005C122927707 @default.
• W2004156005 hasConceptScore W2004156005C148738053 @default.
• W2004156005 hasConceptScore W2004156005C171089720 @default.
• W2004156005 hasConceptScore W2004156005C178790620 @default.
• W2004156005 hasConceptScore W2004156005C185592680 @default.
• W2004156005 hasConceptScore W2004156005C198826908 @default.
• W2004156005 hasConceptScore W2004156005C28328180 @default.
• W2004156005 hasConceptScore W2004156005C2993207723 @default.
• W2004156005 hasConceptScore W2004156005C35496256 @default.
• W2004156005 hasConceptScore W2004156005C540031477 @default.
• W2004156005 hasConceptScore W2004156005C55493867 @default.
• W2004156005 hasConceptScore W2004156005C7836513 @default.
• W2004156005 hasConceptScore W2004156005C86803240 @default.

• next