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• W2004156502 endingPage "87" @default.
• W2004156502 startingPage "79" @default.
• W2004156502 abstract "The basolateral membranes of intestinal M cells are invaginated to form large intraepithelial “pockets” that are populated by specific sub-sets of mucosal leukocytes, including CD4+ T cells, memory and naïve B cells, and occasional dendritic cells. The adhesion molecules involved in leukocyte trafficking and/or retention within this unique immunological niche are unknown. In this study, we used immunofluorescence microscopy and a battery of monoclonal antibodies to identify the adhesion molecules expressed by leukocytes situated within the intracellular pockets of mouse Peyer's patch (PP) M cells. M cell associated leukocytes (MAL) consistently stained positive for integrin α4β7, and integrin LFA-1 (CD11a/CD18), but were rarely positive for L-selectin (CD62L) or the mucosal integrin αEβ7. However, neither the α4β7 ligands MadCAM-1 or VCAM-1, nor the LFA-1 ligand ICAM-1, were detected on M cell basolateral membranes. To determine whether integrins α4β7 or LFA-1 play a functional role leukocyte homing to M cell pockets, we examined M cells in mice deficient in integrin β7 or CD11a/CD18. Although PP from CD18-/- or integrin β7-/- mice were reduced in number and size as compared to age-matched controls, we identified M cells in both strains of mice. However, mice lacking CD18 (but not integrin β7) had significantly fewer leukocytes within M cell pockets as compared to control animals, suggesting LFA-1 (but not α4β7) may contribute, in part, to leukocyte trafficking into and/or retention within this unique immunological niche." @default.
• W2004156502 created "2016-06-24" @default.
• W2004156502 creator A5039380118 @default.
• W2004156502 creator A5084071646 @default.
• W2004156502 date "2004-02-01" @default.
• W2004156502 modified "2023-10-16" @default.
• W2004156502 title "Analysis of Adhesion Molecules Involved in Leukocyte Homing into the Basolateral Pockets of Mouse Peyer's Patch M Cells" @default.
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• W2004156502 doi "https://doi.org/10.1080/10611860410001693724" @default.
• W2004156502 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15203901" @default.
• W2004156502 hasPublicationYear "2004" @default.
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