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• W2004161470 abstract "Simplified representations can be powerful. Two common examples are sequence logos and ribbon diagrams. Both have been extraordinarily successful in capturing complex static features of sequences and structures. Capturing function is challenging, since activation involves triggered dynamic shifts between ON and OFF states. Here, we show that simple funnel drawings can capture and usefully portray proteins by their cellular triggering mechanism. The funnel shape around the proteins' native states can describe mechanisms of upstream signal integration and downstream response. Function diagrams are important: they can combine diverse biochemical data to visually distinguish among activation (or recruitment) mechanisms and tag proteins in cellular networks, clarifying their mechanism at a glance. We create templates for function classification and suggest that they can extend signaling pathway maps. Of note, the diagrams describe free energy landscapes; thus, they can be quantified. We name our dynamic free-energy diagrams dFEDs." @default.
• W2004161470 created "2016-06-24" @default.
• W2004161470 creator A5020262392 @default.
• W2004161470 creator A5025357844 @default.
• W2004161470 date "2014-03-01" @default.
• W2004161470 modified "2023-10-07" @default.
• W2004161470 title "Free Energy Diagrams for Protein Function" @default.
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• W2004161470 doi "https://doi.org/10.1016/j.chembiol.2013.12.015" @default.
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