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• W2004163058 endingPage "1243" @default.
• W2004163058 startingPage "1233" @default.
• W2004163058 abstract "Recent research in ruminant nutrit ion and metabolism has focused attention on l ipid utilization and l ipid-protein interactions. F o r example, Varman and Schultz (82) have reported altered levels of lipids in the blood stream of cows with depressed fa t test. McCarthy et al. (48) observed alterations in the serum lipoproteins of cows with bovine ketosis and also in animals with depressed fat test. The experiments of Chandler et al. (13) demonstrated an interaction between l ipid and protein in the diet of young growing calves. With the increased interest in l ipid metabolism, it seems appropr ia te to review the current understanding of l ipoproteins and their metabolism. Since none of the lipids that occur in blood are sufficiently polar to circulate free in this aqueous solution (22), a mechanism must be present to achieve a transportable form. One manner in which nonpotar substances can be made soluble in polar solvents is to complex them with highly polar molecules such as proteins. I t was observed in 1901 (30) that such l ipid-protein complexes did occur in the blood of animals. The true metabolic significance of this observation has been appreciated only during the last 20 years. Epstein et al. (18) in 1922 observed that the levels of serum cholesterol and serum protein were negatively correlated with the basal metabolic rate and concluded that this indicated an increased turnover of these molecules. Although Epstein was unaware of i t at the time, this early report was one of the first to indicate the importance of l ipid-protein macromolecules in plasma nutr ient transport . Lipid-protein complexes, or lipoproteins, have been studied only recently ha ruminants. Their relative importance in metabolism has been compared with glucose and acetate in the study of milk fa t synthesis with goats (4) and with lactating dairy cows (25). Serum chylomicrons and low-density l ipoproteins were the major blood precursors for milk fa t synthesis in these experiments. The uptake of triglycerides of low-density l ipoproteins by" @default.
• W2004163058 created "2016-06-24" @default.
• W2004163058 creator A5065177822 @default.
• W2004163058 creator A5077090350 @default.
• W2004163058 date "1969-08-01" @default.
• W2004163058 modified "2023-10-18" @default.
• W2004163058 title "Blood Serum Lipoproteins: A review" @default.
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• W2004163058 doi "https://doi.org/10.3168/jds.s0022-0302(69)86731-7" @default.
• W2004163058 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/4905545" @default.
• W2004163058 hasPublicationYear "1969" @default.
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