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- W2004163205 abstract "Unincubated eggs were injected with spermine (2.61–10 mg/egg) and incubated for 1–7 days. Morphogenetic and histogenetic study of the recovered embryos indicated a teratogenic action of the agent. Abnormalities consisted of lack of head flexures, asymmetry, and general arrest of development at about stage 17. A few bizarre conditions occurred: some specimens consisted of nothing but blood sacs; in a few the neural tube was thrown into highly convoluted folds. The histological picture also indicated a general arrest of development at about stage 17: cells of the neural tube were disaggregated at abrupt points and moved out of the wall, taking a more rounded, smaller form. The most striking change pertained to the blood cells. Whereas day-7 control embryos had mature erythrocytes, the spermine-treated ones showed a proliferation of immature erythrocytes in the vessels, heart, and head, which often completely filled these organs." @default.
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- W2004163205 date "1972-10-01" @default.
- W2004163205 modified "2023-09-27" @default.
- W2004163205 title "Action of spermine on early chick development. I. Morphogenesis and histogenesis" @default.
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- W2004163205 doi "https://doi.org/10.1002/tera.1420060209" @default.
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