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• W2004163798 startingPage "209" @default.
• W2004163798 abstract "The gene (PP63) encoding the inhibitor (PP63) of the insulin receptor tyrosine kinase was isolated from a rat genomic library. The intron/exon organization was deduced from Southern-blot analysis and sequence data (i.e., the exons + the boundaries). The PP63 gene, which maps to chromosome 11, spans approx. 8 kb and contains seven exons separated by six introns of different sizes. All of the boundaries match the consensus GT/AG sequence for donor and acceptor splice sites. Primer extension and S l mapping experiments were used to locate the transcription start point (tsp) 73 nt upstream from the translational initiator. Both in vitro transcription assays and transcription of a chimeric gene in intact hepatoma cells indicated that the sequence located immediately upstream from the tsp contained a promoter. Several putative cis-regulatory elements, including a TATA box and a C/EBP-binding site were found within the 250 bp preceding the tsp." @default.
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• W2004163798 date "1991-02-01" @default.
• W2004163798 modified "2023-10-17" @default.
• W2004163798 title "Primary structure of the rat gene encoding an inhibitor of the insulin receptor tyrosine kinase" @default.
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• W2004163798 doi "https://doi.org/10.1016/0378-1119(91)90175-b" @default.
• W2004163798 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1849862" @default.
• W2004163798 hasPublicationYear "1991" @default.
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