FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2004165208> ?p ?o ?g. }

• W2004165208 endingPage "571" @default.
• W2004165208 startingPage "562" @default.
• W2004165208 abstract "IntroductionLittle evidence is available on the natural course of osteoarthritis (OA) development and the genes that protect and predispose individuals to it. This study was designed to compare strain-dependent development of OA and its association with tissue regeneration in mice. Two recombinant inbred lines LGXSM-6 and LGXSM-33 generated from LG/J and SM/J intercross were used. Previous studies indicated that LGXSM-6 can regenerate both articular cartilage and ear hole punch while LGXSM-33 cannot.MethodsTransection of the medial meniscotibial ligament was performed on 10-week-old male mice to induce OA. Cartilage damage was analyzed by histology and bone morphology was evaluated using micro-computed tomography (CT). Ear punches were performed and evaluated by measurement of residual hole diameter.ResultsCartilage analysis showed that LGXSM-33 developed a significantly higher grade of OA than LGXSM-6. Bone analysis showed that LGXSM-33 had substantial subchondral bone and trabecular bone thickening 8 weeks post-surgery, while LGXSM-6 showed bone loss over time. We also confirmed that LGXSM-6 can heal ear tissues significantly better than LGXSM-33.ConclusionsOA was found to be negatively correlated with the degree of tissue regeneration. LGXSM-33, a poor healer of ear tissues (and articular cartilage), developed more OA compared to LGXSM-6, which had better regenerative ability for ear tissues and articular cartilage. The phenotypic differences observed here are due to genetic differences further suggesting that similar sets of physiological processes and gene variants may mediate variation in OA development and tissue regeneration." @default.
• W2004165208 created "2016-06-24" @default.
• W2004165208 creator A5020836537 @default.
• W2004165208 creator A5023251060 @default.
• W2004165208 creator A5065368485 @default.
• W2004165208 creator A5082172901 @default.
• W2004165208 creator A5087500022 @default.
• W2004165208 date "2012-06-01" @default.
• W2004165208 modified "2023-10-12" @default.
• W2004165208 title "Cartilage and bone changes during development of post-traumatic osteoarthritis in selected LGXSM recombinant inbred mice" @default.
• W2004165208 cites W1978118701 @default.
• W2004165208 cites W1983832419 @default.
• W2004165208 cites W1985935486 @default.
• W2004165208 cites W1988478402 @default.
• W2004165208 cites W1992417560 @default.
• W2004165208 cites W1993770134 @default.
• W2004165208 cites W1999770057 @default.
• W2004165208 cites W2003508313 @default.
• W2004165208 cites W2003867697 @default.
• W2004165208 cites W2004519673 @default.
• W2004165208 cites W2009627812 @default.
• W2004165208 cites W2029093699 @default.
• W2004165208 cites W2034384516 @default.
• W2004165208 cites W2035342682 @default.
• W2004165208 cites W2054837142 @default.
• W2004165208 cites W2054881132 @default.
• W2004165208 cites W2057311314 @default.
• W2004165208 cites W2059155774 @default.
• W2004165208 cites W2062266932 @default.
• W2004165208 cites W2088657142 @default.
• W2004165208 cites W2097861097 @default.
• W2004165208 cites W2101873940 @default.
• W2004165208 cites W2102343281 @default.
• W2004165208 cites W2107101733 @default.
• W2004165208 cites W2115435552 @default.
• W2004165208 cites W2120729899 @default.
• W2004165208 cites W2127383554 @default.
• W2004165208 cites W2149011053 @default.
• W2004165208 cites W2152556669 @default.
• W2004165208 cites W2167301035 @default.
• W2004165208 cites W22104415 @default.
• W2004165208 cites W2225337796 @default.
• W2004165208 cites W4232024554 @default.
• W2004165208 cites W4232900352 @default.
• W2004165208 cites W4297755929 @default.
• W2004165208 doi "https://doi.org/10.1016/j.joca.2012.01.022" @default.
• W2004165208 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3353722" @default.
• W2004165208 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22361237" @default.
• W2004165208 hasPublicationYear "2012" @default.
• W2004165208 type Work @default.
• W2004165208 sameAs 2004165208 @default.
• W2004165208 citedByCount "49" @default.
• W2004165208 countsByYear W20041652082012 @default.
• W2004165208 countsByYear W20041652082013 @default.
• W2004165208 countsByYear W20041652082014 @default.
• W2004165208 countsByYear W20041652082015 @default.
• W2004165208 countsByYear W20041652082016 @default.
• W2004165208 countsByYear W20041652082017 @default.
• W2004165208 countsByYear W20041652082018 @default.
• W2004165208 countsByYear W20041652082019 @default.
• W2004165208 countsByYear W20041652082020 @default.
• W2004165208 countsByYear W20041652082021 @default.
• W2004165208 countsByYear W20041652082022 @default.
• W2004165208 countsByYear W20041652082023 @default.
• W2004165208 crossrefType "journal-article" @default.
• W2004165208 hasAuthorship W2004165208A5020836537 @default.
• W2004165208 hasAuthorship W2004165208A5023251060 @default.
• W2004165208 hasAuthorship W2004165208A5065368485 @default.
• W2004165208 hasAuthorship W2004165208A5082172901 @default.
• W2004165208 hasAuthorship W2004165208A5087500022 @default.
• W2004165208 hasBestOaLocation W20041652081 @default.
• W2004165208 hasConcept C104317684 @default.
• W2004165208 hasConcept C105702510 @default.
• W2004165208 hasConcept C142724271 @default.
• W2004165208 hasConcept C171056886 @default.
• W2004165208 hasConcept C204787440 @default.
• W2004165208 hasConcept C2776164576 @default.
• W2004165208 hasConcept C2780550940 @default.
• W2004165208 hasConcept C2781013607 @default.
• W2004165208 hasConcept C3020332539 @default.
• W2004165208 hasConcept C55493867 @default.
• W2004165208 hasConcept C57742111 @default.
• W2004165208 hasConcept C71924100 @default.
• W2004165208 hasConcept C76725341 @default.
• W2004165208 hasConcept C86803240 @default.
• W2004165208 hasConcept C95444343 @default.
• W2004165208 hasConceptScore W2004165208C104317684 @default.
• W2004165208 hasConceptScore W2004165208C105702510 @default.
• W2004165208 hasConceptScore W2004165208C142724271 @default.
• W2004165208 hasConceptScore W2004165208C171056886 @default.
• W2004165208 hasConceptScore W2004165208C204787440 @default.
• W2004165208 hasConceptScore W2004165208C2776164576 @default.
• W2004165208 hasConceptScore W2004165208C2780550940 @default.
• W2004165208 hasConceptScore W2004165208C2781013607 @default.
• W2004165208 hasConceptScore W2004165208C3020332539 @default.
• W2004165208 hasConceptScore W2004165208C55493867 @default.
• W2004165208 hasConceptScore W2004165208C57742111 @default.
• W2004165208 hasConceptScore W2004165208C71924100 @default.

• next