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- W2004169627 abstract "Abstract Low dose heparin therapy has been used routinely for prophylaxis of deep venous thrombosis, yet in vitro data regarding its antithrombotic effects are sparse. The effects of heparin on venous thrombus formation were studied in an in vitro perfusion system. Fresh blood collected from human volunteers was treated with varying heparin doses and perfused at a shear rate of 100 sec −1 over everted, injured porcine vein segments, simulating conditions in the venous circulation. Platelet and fibrin deposition were measured by use of indium 111 and iodine 125 radiolabels, respectively. The effects of heparin on the intrinsic coagulation cascade were monitored by the activated clotting time. Increasing doses of heparin resulted in significant reductions in fibrin and platelet deposition (ANOVA F=2.67 and 3.17, respectively, p" @default.
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- W2004169627 date "1991-11-01" @default.
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- W2004169627 title "Low dose heparin therapy: In vitro verification of antithrombotic effect" @default.
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- W2004169627 doi "https://doi.org/10.1016/0741-5214(91)90186-x" @default.
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