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- W2004170342 abstract "Tyrosinase is one of the key enzymes essential for melanogenesis. The control of its activity rests in part at the level of transcriptional regulation. The 5' promoter regions of the human, mouse, chicken, quail, snapping turtle, and frog tyrosinase sequences have been isolated and the mechanisms regulating the activity of these sequences are beginning to be elucidated. This review provides an update on the following aspects of tyrosinase gene regulation: basal promoter elements that determine the site of transcription initiation for RNA polymerase II; the cis-acting elements and DNA-binding factors that mediate melanocyte-specific expression of the tyrosinase gene; promoter elements involved in the temporal control of tyrosinase gene expression; additional elements that may be required to achieve wild-type levels of gene expression; and specific elements that may be required for modulation of tyrosinase gene expression in response to humoral factors or external stimuli that are known to influence the amounts of melanin synthesized by fully differentiated melanocytes. The wild type expression of tyrosinase is the result of the interaction of many different factors and it is becoming evident that certain elements and factors play more than one role in this process." @default.
- W2004170342 created "2016-06-24" @default.
- W2004170342 creator A5055782758 @default.
- W2004170342 creator A5070302335 @default.
- W2004170342 date "1997-06-01" @default.
- W2004170342 modified "2023-10-13" @default.
- W2004170342 title "The Regulation of Tyrosinase Gene Transcription" @default.
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- W2004170342 doi "https://doi.org/10.1111/j.1600-0749.1997.tb00474.x" @default.
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