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- W2004172605 abstract "To determine the significance of age on the response of tumor-bearing animals to chemotherapy, the effects of several compounds on established LPC-I plasma cell tumor were compared in young (2-3 mo.) and old (18-25 mo.) isogeneic female BALB/c mice. The median survival time (MST) of untreated tumor-bearing mice was significantly longer for old than for young (7 experiments, consisting of a total of 187 and 162 mice, respectively). T/C (MST of treated/MST of corresponding control) was greater in young than in old mice treated with cyclophosphamide or 1,3-diallylurea, and with 5-fluorouracil at the higher dose, but the reverse was true in the case of l,3-bis-(2-chloroethyl)-1-nitrosourea. An additional supportive finding with 5-fluorouracil was that 87% of young, compared with 24% of old mice remained in remission 90 days after initiation of therapy." @default.
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- W2004172605 date "1974-07-01" @default.
- W2004172605 modified "2023-10-17" @default.
- W2004172605 title "Influence of Age of Host on the Chemotherapy of Murine Myeloma LCP-1" @default.
- W2004172605 doi "https://doi.org/10.1093/geronj/29.4.360" @default.
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