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- W2004173608 abstract "Abstract Smooth and rough microsomal membranes, prepared by density gradient centrifugation from livers of mice, guinea pigs and monkeys, were compared on the basis of biochemical composition, enzyme distribution, and fine structure. Phospholipid and cholesterol distribution varied considerably between smooth and rough membranes and between animal species. The following components of microsomal drug metabolism were studied: ethylmorphine demethylase, l -benzphetamine demethylase, aniline hydroxylase, NADPH cytochrome c reductase, cytochrome P-450, and spectral changes resulting from microsome-substrate interaction. Expressed per milligram of protein, all these components were concentrated about 2-fold in the smooth membranes of monkey and guinea pig liver, but were approximately evenly distributed between smooth and rough membranes of mouse liver. The results support the concept of heterogeneity among microsomal membranes. In addition to the well recognized species differences in microsomal drug metabolism, our data indicate important species differences in submicrosomal membrane composition and enzyme distribution." @default.
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- W2004173608 date "1971-07-01" @default.
- W2004173608 modified "2023-10-03" @default.
- W2004173608 title "Enzymic and biochemical composition of smooth and rough microsomal membranes from monkey, guinea pig and mouse liver" @default.
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- W2004173608 doi "https://doi.org/10.1016/0006-2952(71)90264-4" @default.
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