FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2004173797> ?p ?o ?g. }

• W2004173797 endingPage "e1000945" @default.
• W2004173797 startingPage "e1000945" @default.
• W2004173797 abstract "The interaction between fungal pathogens with the host frequently results in morphological changes, such as hyphae formation. The encapsulated pathogenic fungus Cryptococcus neoformans is not considered a dimorphic fungus, and is predominantly found in host tissues as round yeast cells. However, there is a specific morphological change associated with cryptococcal infection that involves an increase in capsule volume. We now report another morphological change whereby gigantic cells are formed in tissue. The paper reports the phenotypic characterization of giant cells isolated from infected mice and the cellular changes associated with giant cell formation. C. neoformans infection in mice resulted in the appearance of giant cells with cell bodies up to 30 microm in diameter and capsules resistant to stripping with gamma-radiation and organic solvents. The proportion of giant cells ranged from 10 to 80% of the total lung fungal burden, depending on infection time, individual mice, and correlated with the type of immune response. When placed on agar, giant cells budded to produce small daughter cells that traversed the capsule of the mother cell at the speed of 20-50 m/h. Giant cells with dimensions that approximated those in vivo were observed in vitro after prolonged culture in minimal media, and were the oldest in the culture, suggesting that giant cell formation is an aging-dependent phenomenon. Giant cells recovered from mice displayed polyploidy, suggesting a mechanism by which gigantism results from cell cycle progression without cell fission. Giant cell formation was dependent on cAMP, but not on Ras1. Real-time imaging showed that giant cells were engaged, but not engulfed by phagocytic cells. We describe a remarkable new strategy for C. neoformans to evade the immune response by enlarging cell size, and suggest that gigantism results from replication without fission, a phenomenon that may also occur with other fungal pathogens." @default.
• W2004173797 created "2016-06-24" @default.
• W2004173797 creator A5001312410 @default.
• W2004173797 creator A5008350779 @default.
• W2004173797 creator A5033015820 @default.
• W2004173797 creator A5049860395 @default.
• W2004173797 creator A5072838367 @default.
• W2004173797 creator A5077902719 @default.
• W2004173797 date "2010-06-17" @default.
• W2004173797 modified "2023-10-14" @default.
• W2004173797 title "Fungal Cell Gigantism during Mammalian Infection" @default.
• W2004173797 cites W14003297 @default.
• W2004173797 cites W1490724351 @default.
• W2004173797 cites W1520644343 @default.
• W2004173797 cites W1523935689 @default.
• W2004173797 cites W1607519730 @default.
• W2004173797 cites W1754630493 @default.
• W2004173797 cites W1756493790 @default.
• W2004173797 cites W1767583780 @default.
• W2004173797 cites W1912200926 @default.
• W2004173797 cites W1935355922 @default.
• W2004173797 cites W1939001682 @default.
• W2004173797 cites W1964849586 @default.
• W2004173797 cites W1976914087 @default.
• W2004173797 cites W1982363838 @default.
• W2004173797 cites W2000371716 @default.
• W2004173797 cites W2002379595 @default.
• W2004173797 cites W2008919704 @default.
• W2004173797 cites W2011758386 @default.
• W2004173797 cites W2013686234 @default.
• W2004173797 cites W2030303101 @default.
• W2004173797 cites W2038215655 @default.
• W2004173797 cites W2049658102 @default.
• W2004173797 cites W2052789908 @default.
• W2004173797 cites W2055437490 @default.
• W2004173797 cites W2055698166 @default.
• W2004173797 cites W2057747682 @default.
• W2004173797 cites W2062406170 @default.
• W2004173797 cites W2062709789 @default.
• W2004173797 cites W2067007577 @default.
• W2004173797 cites W2075929894 @default.
• W2004173797 cites W2077306158 @default.
• W2004173797 cites W2079513681 @default.
• W2004173797 cites W2086181643 @default.
• W2004173797 cites W2094032599 @default.
• W2004173797 cites W2096323533 @default.
• W2004173797 cites W2099723019 @default.
• W2004173797 cites W2100317350 @default.
• W2004173797 cites W2100387642 @default.
• W2004173797 cites W2103654565 @default.
• W2004173797 cites W2112243625 @default.
• W2004173797 cites W2113470924 @default.
• W2004173797 cites W2115088827 @default.
• W2004173797 cites W2116179338 @default.
• W2004173797 cites W2116453842 @default.
• W2004173797 cites W2118303562 @default.
• W2004173797 cites W2119935989 @default.
• W2004173797 cites W2128826382 @default.
• W2004173797 cites W2131659299 @default.
• W2004173797 cites W2134546075 @default.
• W2004173797 cites W2143286751 @default.
• W2004173797 cites W2147526235 @default.
• W2004173797 cites W2148154753 @default.
• W2004173797 cites W2148591934 @default.
• W2004173797 cites W2150822410 @default.
• W2004173797 cites W2151396669 @default.
• W2004173797 cites W2151657112 @default.
• W2004173797 cites W2154947150 @default.
• W2004173797 cites W2156503168 @default.
• W2004173797 cites W2158014005 @default.
• W2004173797 cites W2158576875 @default.
• W2004173797 cites W2160854136 @default.
• W2004173797 cites W2162644900 @default.
• W2004173797 cites W2167737387 @default.
• W2004173797 cites W2312534394 @default.
• W2004173797 cites W4240445572 @default.
• W2004173797 cites W4252405503 @default.
• W2004173797 cites W4253413900 @default.
• W2004173797 cites W5923498 @default.
• W2004173797 doi "https://doi.org/10.1371/journal.ppat.1000945" @default.
• W2004173797 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2887474" @default.
• W2004173797 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20585557" @default.
• W2004173797 hasPublicationYear "2010" @default.
• W2004173797 type Work @default.
• W2004173797 sameAs 2004173797 @default.
• W2004173797 citedByCount "260" @default.
• W2004173797 countsByYear W20041737972012 @default.
• W2004173797 countsByYear W20041737972013 @default.
• W2004173797 countsByYear W20041737972014 @default.
• W2004173797 countsByYear W20041737972015 @default.
• W2004173797 countsByYear W20041737972016 @default.
• W2004173797 countsByYear W20041737972017 @default.
• W2004173797 countsByYear W20041737972018 @default.
• W2004173797 countsByYear W20041737972019 @default.
• W2004173797 countsByYear W20041737972020 @default.
• W2004173797 countsByYear W20041737972021 @default.
• W2004173797 countsByYear W20041737972022 @default.
• W2004173797 countsByYear W20041737972023 @default.

• next