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• W2004173887 abstract "β-Catenin signaling is required for hair follicle development, but it is unknown whether its activation is sufficient to globally program embryonic epidermis to hair follicle fate. To address this, we mutated endogenous epithelial β-catenin to a dominant-active form in vivo. Hair follicle placodes were expanded and induced prematurely in activated β-catenin mutant embryos, but failed to invaginate or form multilayered structures. Eventually, the entire epidermis adopted hair follicle fate, broadly expressing hair shaft keratins in place of epidermal stratification proteins. Mutant embryonic skin was precociously innervated, and displayed prenatal pigmentation, a phenomenon never observed in wild-type controls. Thus,β-catenin signaling programs the epidermis towards placode and hair shaft fate at the expense of epidermal differentiation, and activates signals directing pigmentation and innervation. In transcript profiling experiments,we identified elevated expression of Sp5, a direct β-catenin target and transcriptional repressor. We show that Sp5 normally localizes to hair follicle placodes and can suppress epidermal differentiation gene expression. We identified the pigmentation regulators Foxn1,Adamts20 and Kitl, and the neural guidance genes Sema4c,Sema3c, Unc5b and Unc5c, as potential mediators of the effects of β-catenin signaling on pigmentation and innervation. Our data provide evidence for a new paradigm in which, in addition to promoting hair follicle placode and hair shaft fate, β-catenin signaling actively suppresses epidermal differentiation and directs pigmentation and nerve fiber growth. Controlled downregulation of β-catenin signaling is required for normal placode patterning within embryonic ectoderm, hair follicle downgrowth, and adoption of the full range of follicular fates." @default.
• W2004173887 created "2016-06-24" @default.
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• W2004173887 date "2008-06-15" @default.
• W2004173887 modified "2023-10-16" @default.
• W2004173887 title "Activation of β-catenin signaling programs embryonic epidermis to hair follicle fate" @default.
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• W2004173887 doi "https://doi.org/10.1242/dev.017459" @default.
• W2004173887 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2516408" @default.
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• W2004173887 hasPublicationYear "2008" @default.
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