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- W2004175050 abstract "A monoclonal antibody CWE4 was produced against the 60-kilodalton (kDa) antigen of Candida albicans. Previously we demonstrated that antibody to this antigen was the second most commonly produced in patients with systemic candidiasis. Immunoelectron microscopy demonstrated reactivity of CWE4 with a nuclear component in yeast and mycelial cells. It was a high affinity IgG immunoglobulin. CWE4 was incorporated in a dot immunobinding assay to detect circulating 60 kDa antigen in sera from patients with systemic candidiasis. It was much more sensitive than reverse passive latex agglutination (RPLA), being positive in 69% of neutropenic patients and 80% of non-neutropenic patients, compared to 33% and 68% respectively with RPLA. False positives were rare among uninfected controls but common among superficially infected and colonized patients. In a mouse model of candidal peritonitis, CWE4 compared unfavourably with a rabbit hyperimmune candidal antiserum in its ability to reduce the severity of infection." @default.
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- W2004175050 date "1989-04-01" @default.
- W2004175050 modified "2023-10-18" @default.
- W2004175050 title "The diagnostic and therapeutic potential of a monoclonal antibody to the 60-kilodalton nuclear antigen of Candida albicans" @default.
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- W2004175050 doi "https://doi.org/10.1016/0888-0786(89)90045-0" @default.
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