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• W2004178416 abstract "A series of substituted azole derivatives (3a–e, 4a–e and 5a–e) were synthesised by the cyclisation of N1(diphenylethanoyl)-N4-substituted phenyl thiosemicarbazides under various reaction conditions. These compounds were tested in vivo for their anti-inflammatory activity. The compounds which showed activity comparable to the standard drug ibuprofen, were screened for their analgesic, ulcerogenic and lipid peroxidation activities. The compounds 5-(diphenylmethyl)-N-(4-fluorophenyl)-1,3,4-oxadiazol-2-amine (3b) and 5-(diphenylmethyl)-N-(3-chloro-4-fluorophenyl)-1,3,4-oxadiazol-2-amine (3c) emerged as the most active compounds of the series, and were moderately more potent than the standard drug, ibuprofen. (This abstract was published in Inflammation Research, Supplement 2, Volume 56, page A101, 2008.)" @default.
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• W2004178416 date "2010-06-28" @default.
• W2004178416 modified "2023-10-18" @default.
• W2004178416 title "Design, synthesis and pharmacological evaluation of novel azole derivatives of aryl acetic acid as anti-inflammatory and analgesic agents" @default.
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• W2004178416 doi "https://doi.org/10.3109/14756366.2010.481622" @default.
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