FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2004180724> ?p ?o ?g. }

• W2004180724 endingPage "212" @default.
• W2004180724 startingPage "205" @default.
• W2004180724 abstract "Prostate cancer is a global health issue. Usually, men with metastatic disease will progress to castration-resistant prostate cancer (CRPC). We aimed to identify the differentially expressed genes (DEGs) in tumor samples from non-castrated and castrated men from LNCaP Orthotopic xenograft models of prostate cancer and to study the mechanisms of CRPC.In this work, GSE46218 containing 4 samples from non-castrated men and 4 samples from castrated men was downloaded from Gene Expression Omnibus. We identified DEGs using limma Geoquery in R, the Robust Multi-array Average (RMA) method in Bioconductor, and Bias methods, followed by constructing an integrated regulatory network involving DEGs, miRNAs, and TFs using Cytoscape. Then, we analyzed network motifs of the integrated gene regulatory network using FANMOD. We selected regulatory modules corresponding to network motifs from the integrated regulatory network by Perl script. We preformed gene ontology (GO) and pathway enrichment analysis of DEGs in the regulatory modules using DAVID.We identified total 443 DEGs. We built an integrated regulatory network, found three motifs (motif 1, motif 2 and motif 3), and got two function modules (module 1 corresponded to motif 1, and module 2 corresponded to motif 2). Several GO terms (such as regulation of cell proliferation, positive regulation of macromolecule metabolic process, phosphorylation, and phosphorus metabolic process) and two pathways (pathway in cancer and Melanoma) were enriched. Furthermore, some significant DEGs (such as CAV1, LYN, FGFR3 and FGFR3) were related to CPRC development.These genes might play important roles in the development and progression of CRPC." @default.
• W2004180724 created "2016-06-24" @default.
• W2004180724 creator A5015984403 @default.
• W2004180724 creator A5048679935 @default.
• W2004180724 creator A5063815505 @default.
• W2004180724 creator A5079679645 @default.
• W2004180724 creator A5087864493 @default.
• W2004180724 creator A5090926889 @default.
• W2004180724 date "2015-01-01" @default.
• W2004180724 modified "2023-09-25" @default.
• W2004180724 title "Gene Expression Profiling Analysis of Castration-Resistant Prostate Cancer" @default.
• W2004180724 cites W1498647927 @default.
• W2004180724 cites W1580852618 @default.
• W2004180724 cites W1963691340 @default.
• W2004180724 cites W1973430254 @default.
• W2004180724 cites W1980485261 @default.
• W2004180724 cites W1995331075 @default.
• W2004180724 cites W2003448771 @default.
• W2004180724 cites W2009785086 @default.
• W2004180724 cites W2017199818 @default.
• W2004180724 cites W2027406112 @default.
• W2004180724 cites W2049532025 @default.
• W2004180724 cites W2064757019 @default.
• W2004180724 cites W2071404469 @default.
• W2004180724 cites W2072891243 @default.
• W2004180724 cites W2082856827 @default.
• W2004180724 cites W2102768326 @default.
• W2004180724 cites W2106054588 @default.
• W2004180724 cites W2108057299 @default.
• W2004180724 cites W2112262143 @default.
• W2004180724 cites W2128768066 @default.
• W2004180724 cites W2134118500 @default.
• W2004180724 cites W2135833373 @default.
• W2004180724 cites W2142435450 @default.
• W2004180724 cites W2148416479 @default.
• W2004180724 cites W2153234291 @default.
• W2004180724 cites W2158217645 @default.
• W2004180724 cites W2159675211 @default.
• W2004180724 cites W2169489936 @default.
• W2004180724 cites W2171322586 @default.
• W2004180724 cites W2328105863 @default.
• W2004180724 doi "https://doi.org/10.12659/msm.891193" @default.
• W2004180724 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4306671" @default.
• W2004180724 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25592164" @default.
• W2004180724 hasPublicationYear "2015" @default.
• W2004180724 type Work @default.
• W2004180724 sameAs 2004180724 @default.
• W2004180724 citedByCount "9" @default.
• W2004180724 countsByYear W20041807242015 @default.
• W2004180724 countsByYear W20041807242016 @default.
• W2004180724 countsByYear W20041807242017 @default.
• W2004180724 countsByYear W20041807242018 @default.
• W2004180724 countsByYear W20041807242019 @default.
• W2004180724 countsByYear W20041807242020 @default.
• W2004180724 countsByYear W20041807242021 @default.
• W2004180724 countsByYear W20041807242023 @default.
• W2004180724 crossrefType "journal-article" @default.
• W2004180724 hasAuthorship W2004180724A5015984403 @default.
• W2004180724 hasAuthorship W2004180724A5048679935 @default.
• W2004180724 hasAuthorship W2004180724A5063815505 @default.
• W2004180724 hasAuthorship W2004180724A5079679645 @default.
• W2004180724 hasAuthorship W2004180724A5087864493 @default.
• W2004180724 hasAuthorship W2004180724A5090926889 @default.
• W2004180724 hasBestOaLocation W20041807242 @default.
• W2004180724 hasConcept C104317684 @default.
• W2004180724 hasConcept C121608353 @default.
• W2004180724 hasConcept C150194340 @default.
• W2004180724 hasConcept C165864922 @default.
• W2004180724 hasConcept C18431079 @default.
• W2004180724 hasConcept C2776235491 @default.
• W2004180724 hasConcept C2779723316 @default.
• W2004180724 hasConcept C2780192828 @default.
• W2004180724 hasConcept C502942594 @default.
• W2004180724 hasConcept C54355233 @default.
• W2004180724 hasConcept C67339327 @default.
• W2004180724 hasConcept C70721500 @default.
• W2004180724 hasConcept C86803240 @default.
• W2004180724 hasConceptScore W2004180724C104317684 @default.
• W2004180724 hasConceptScore W2004180724C121608353 @default.
• W2004180724 hasConceptScore W2004180724C150194340 @default.
• W2004180724 hasConceptScore W2004180724C165864922 @default.
• W2004180724 hasConceptScore W2004180724C18431079 @default.
• W2004180724 hasConceptScore W2004180724C2776235491 @default.
• W2004180724 hasConceptScore W2004180724C2779723316 @default.
• W2004180724 hasConceptScore W2004180724C2780192828 @default.
• W2004180724 hasConceptScore W2004180724C502942594 @default.
• W2004180724 hasConceptScore W2004180724C54355233 @default.
• W2004180724 hasConceptScore W2004180724C67339327 @default.
• W2004180724 hasConceptScore W2004180724C70721500 @default.
• W2004180724 hasConceptScore W2004180724C86803240 @default.
• W2004180724 hasLocation W20041807241 @default.
• W2004180724 hasLocation W20041807242 @default.
• W2004180724 hasLocation W20041807243 @default.
• W2004180724 hasLocation W20041807244 @default.
• W2004180724 hasOpenAccess W2004180724 @default.
• W2004180724 hasPrimaryLocation W20041807241 @default.
• W2004180724 hasRelatedWork W1597363747 @default.
• W2004180724 hasRelatedWork W166274801 @default.

• next