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- W2004180922 abstract "We present an exact solution of Eigen’s quasispecies model with a general degradation rate and fitness functions, including a square root decrease of fitness with increasing Hamming distance from the wild type. The found behavior of the model with a degradation rate is analogous to a viral quasispecies under attack by the immune system of the host. Our exact solutions also revise the known results of neutral networks in quasispecies theory. To explain the existence of mutants with large Hamming distances from the wild type, we propose three different modifications of the Eigen model: mutation landscape, multiple adjacent mutations, and frequency-dependent fitness in which the steady-state solution shows a multicenter behavior." @default.
- W2004180922 created "2016-06-24" @default.
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- W2004180922 date "2006-03-20" @default.
- W2004180922 modified "2023-09-27" @default.
- W2004180922 title "Exact solution of the Eigen model with general fitness functions and degradation rates" @default.
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- W2004180922 doi "https://doi.org/10.1073/pnas.0504924103" @default.
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