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• W2004182823 abstract "We investigated the hemodynamic determinants of the age-associated decline in maximal oxygen uptake (V̇o 2 max ) and the influence of gender on the decline in V̇o 2 max and its determinants in old and very old men and women. Sedentary, 60- to 92-yr-old women ( n = 71) and men ( n = 29), with no evidence of cardiovascular disease, underwent maximal treadmill exercise tests during which V̇o 2 max and maximal cardiac output (Q̇ max ) were determined. V̇o 2 max and age were inversely related in both women (−23 ± 2 ml·min −1 ·yr −1 ; P < 0.0001) and men (−57 ± 5 ml·min −1 ·yr −1 ; P < 0.0001). The absolute slope of the V̇o 2 max vs. age relationship was twofold steeper in men than in women ( P < 0.0001). Q̇ max was also inversely related to age in a gender-specific manner (women = −87 ± 25 ml·min −1 ·yr −1 , P = 0.0009; men = −215 ± 50 ml·min −1 ·yr −1 , P = 0.0002; P = 0.01 women vs. men). Age-related changes in maximal exercise arteriovenous oxygen content difference (a-vDo 2 ) were marginally different ( P = 0.08) between women (−0.12 ± 0.03 ml·dl −1 ·yr −1 , P = 0.0003) and men (−0.22 ± 0.04 ml·dl −1 ·yr −1 , P < 0.0001). Age-associated decreases in Q̇ max and a-vDo 2 contributed equally to the declines in V̇o 2 max in both men and women. In the later stages of life, V̇o 2 max , Q̇ max , and a-vDo 2 decrease with age more rapidly in older men than they do in older women. As a result, the gender differences dissipate in the later decades of life. Declines in Q̇ max and a-vDo 2 contribute equally to the age-related decrease in V̇o 2 max in men and women." @default.
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• W2004182823 date "2006-09-01" @default.
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• W2004182823 title "Gender differences in the decline in aerobic capacity and its physiological determinants during the later decades of life" @default.
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• W2004182823 doi "https://doi.org/10.1152/japplphysiol.01398.2005" @default.
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