Matches in SemOpenAlex for { <https://semopenalex.org/work/W2004184946> ?p ?o ?g. }
- W2004184946 endingPage "668" @default.
- W2004184946 startingPage "657" @default.
- W2004184946 abstract "Background: Immunosuppression-related risks are foremost among ethical concerns regarding facial transplantation. However, previous risk estimates are inaccurate and misleading, because they are based on data from studies using different immunosuppression regimens, health status of the transplant recipients, tissue composition, and antigenicity. This review provides a comprehensive risk assessment for facial transplantation based on comparable data of immunosuppression, recipient health status, and composition and antigenicity of the transplanted tissue. Methods: The risk estimates for face transplantation presented here are based on data reported in clinical kidney (10-year experience) and hand transplantation (5-year experience) studies using tacrolimus/mycophenolate mofetil/corticosteroid therapy. Mitigating factors including ease of rejection diagnosis, rejection reversibility, infection prophylaxis, patient selection, and viral serologic status are taken into account. Results: Estimated risks include acute rejection (10 to 70 percent incidence), acute rejection reversibility (approximating 100 percent with corticosteroid therapy alone), chronic rejection (<10 percent over 5 years), cytomegalovirus disease (1 to 15 percent), diabetes (5 to 15 percent), hypertension (5 to 10 percent), and renal failure (<5 percent). Conclusions: A review of these data indicates that previously reported estimates of immunosuppression-related risks are outdated and therefore should no longer be used. These updated risk estimates should be used by facial transplant teams, institutional review boards, and potential recipients when considering the immunologic risks associated with facial transplantation." @default.
- W2004184946 created "2016-06-24" @default.
- W2004184946 creator A5001557559 @default.
- W2004184946 creator A5006876478 @default.
- W2004184946 creator A5027751857 @default.
- W2004184946 creator A5031918132 @default.
- W2004184946 creator A5039709774 @default.
- W2004184946 creator A5039944407 @default.
- W2004184946 creator A5056097283 @default.
- W2004184946 creator A5077252078 @default.
- W2004184946 date "2007-09-01" @default.
- W2004184946 modified "2023-09-25" @default.
- W2004184946 title "Risk Assessment of Immunosuppressive Therapy in Facial Transplantation" @default.
- W2004184946 cites W1968765419 @default.
- W2004184946 cites W1973896688 @default.
- W2004184946 cites W1974698961 @default.
- W2004184946 cites W1974794773 @default.
- W2004184946 cites W1976118007 @default.
- W2004184946 cites W1977589132 @default.
- W2004184946 cites W1977878572 @default.
- W2004184946 cites W1983626252 @default.
- W2004184946 cites W1990118856 @default.
- W2004184946 cites W1991896321 @default.
- W2004184946 cites W1992460455 @default.
- W2004184946 cites W1999294805 @default.
- W2004184946 cites W2000138932 @default.
- W2004184946 cites W2001349326 @default.
- W2004184946 cites W2002894463 @default.
- W2004184946 cites W2007687004 @default.
- W2004184946 cites W2009650987 @default.
- W2004184946 cites W2012426969 @default.
- W2004184946 cites W2013230504 @default.
- W2004184946 cites W2015278968 @default.
- W2004184946 cites W2015498025 @default.
- W2004184946 cites W2018384104 @default.
- W2004184946 cites W2023577731 @default.
- W2004184946 cites W2031643366 @default.
- W2004184946 cites W2034323699 @default.
- W2004184946 cites W2035452994 @default.
- W2004184946 cites W2037438579 @default.
- W2004184946 cites W2037937957 @default.
- W2004184946 cites W2038444464 @default.
- W2004184946 cites W2039924078 @default.
- W2004184946 cites W2044203283 @default.
- W2004184946 cites W2044600432 @default.
- W2004184946 cites W2046490005 @default.
- W2004184946 cites W2047240705 @default.
- W2004184946 cites W2047430642 @default.
- W2004184946 cites W2051849192 @default.
- W2004184946 cites W2053422760 @default.
- W2004184946 cites W2055800571 @default.
- W2004184946 cites W2056610677 @default.
- W2004184946 cites W2059471557 @default.
- W2004184946 cites W2060487753 @default.
- W2004184946 cites W2061253664 @default.
- W2004184946 cites W2062807460 @default.
- W2004184946 cites W2066522448 @default.
- W2004184946 cites W2070102244 @default.
- W2004184946 cites W2073137654 @default.
- W2004184946 cites W2073822242 @default.
- W2004184946 cites W2079384924 @default.
- W2004184946 cites W2080842067 @default.
- W2004184946 cites W2084707936 @default.
- W2004184946 cites W2085164454 @default.
- W2004184946 cites W2086078733 @default.
- W2004184946 cites W2090753747 @default.
- W2004184946 cites W2091713884 @default.
- W2004184946 cites W2091780068 @default.
- W2004184946 cites W2092371213 @default.
- W2004184946 cites W2093765025 @default.
- W2004184946 cites W2094676257 @default.
- W2004184946 cites W2098409340 @default.
- W2004184946 cites W2109917792 @default.
- W2004184946 cites W2112595386 @default.
- W2004184946 cites W2125529763 @default.
- W2004184946 cites W2131598459 @default.
- W2004184946 cites W2134020367 @default.
- W2004184946 cites W2134869152 @default.
- W2004184946 cites W2138260394 @default.
- W2004184946 cites W2146662658 @default.
- W2004184946 cites W2150900225 @default.
- W2004184946 cites W2158984212 @default.
- W2004184946 cites W2174935414 @default.
- W2004184946 cites W2182833791 @default.
- W2004184946 cites W2253134880 @default.
- W2004184946 cites W2332401864 @default.
- W2004184946 cites W3005079460 @default.
- W2004184946 cites W32301231 @default.
- W2004184946 cites W4234392700 @default.
- W2004184946 cites W4240357159 @default.
- W2004184946 cites W4245601015 @default.
- W2004184946 cites W4252361021 @default.
- W2004184946 cites W4321258628 @default.
- W2004184946 cites W50336179 @default.
- W2004184946 doi "https://doi.org/10.1097/01.prs.0000270316.33293.ec" @default.
- W2004184946 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17700117" @default.
- W2004184946 hasPublicationYear "2007" @default.
- W2004184946 type Work @default.