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- W2004185744 abstract "Mathematical models relating observed yield of cancers vs administered radiation dose have become popular in recent years, especially as means of predicting hazards associated with exposure conditions which are beyond the realm of practical experimentation. While the validity of these predictions remains a controversy, these models, especially the αD + βD2 model, have more recently been used to infer the mechanism(s) underlying the carcinogenic process. Through the analysis of simple experimental systems, we demonstrate in this report that aD + bD2 kinetics can result from injury to the cells which eventually develop into the cancer (target cells) or from injury to those cells which affect target cell survival. Further, these kinetics can fail to predict the consequences of dose protraction, largely due to the fact that transformation increases with dose, while survival decreases. The role of these models in helping to develop an understanding of mechanisms should be restricted, therefore, to the formulation of basic hypotheses which are subject to direct testing in the laboratory." @default.
- W2004185744 created "2016-06-24" @default.
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- W2004185744 date "1979-07-01" @default.
- W2004185744 modified "2023-09-23" @default.
- W2004185744 title "Intrinsic and extrinsic variables affecting sensitivity to radiation carcinogenesis" @default.
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- W2004185744 doi "https://doi.org/10.1016/0360-3016(79)90628-x" @default.
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