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- W2004185979 abstract "Neurodegenerative diseases are associated with the accumulation of intracellular or extracellular protein aggregates that form because of protein misfolding. These aggregates are capable of crossing cellular membranes and can thereby directly contribute to the propagation of neurodegenerative disease pathogenesis, which might spread in a 'prion-like' manner. Neurodegenerative diseases are commonly associated with the accumulation of intracellular or extracellular protein aggregates. Recent studies suggest that these aggregates are capable of crossing cellular membranes and can directly contribute to the propagation of neurodegenerative disease pathogenesis. We propose that, once initiated, neuropathological changes might spread in a 'prion-like' manner and that disease progression is associated with the intercellular transfer of pathogenic proteins. The transfer of naked infectious particles between cells could therefore be a target for new disease-modifying therapies." @default.
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- W2004185979 date "2010-04-01" @default.
- W2004185979 modified "2023-10-14" @default.
- W2004185979 title "Prion-like transmission of protein aggregates in neurodegenerative diseases" @default.
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- W2004185979 doi "https://doi.org/10.1038/nrm2873" @default.
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