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- W2004189965 abstract "Abstract Empty and drug-containing albumin muspheres (2–5 μm) produced by an emulsion cross-linking process were presented to mouse peritoneal macrophages. Empty muspheres caused a 36.7 and 43.3% release of β-galactosidase and β-glucuronidase, respectively. The inclusion of prednisolone (19μg/mg), prednisolone succinate (26μg/mg) and methotrexate (50μg/mg) caused a reduction in lysosomal release. Similarly the presence of incorporated anti-inflammatory drugs caused a depression in glycolytic activity, illustrated by monitoring levels of 14 CO 2 . Both effects were found to be dose dependent. This report demonstrates that the possible toxicity of the albumin matrix can be suppressed by inclusion of an anti-inflammatory drug into the musphere. Potentially, this system could be administered by the intra-articular route to deliver steroidal drugs to the synovial joint in order to treat rheumatoid arthritis." @default.
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- W2004189965 date "1991-02-01" @default.
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- W2004189965 title "Effect of uptake of albumin muspheres on cellular activity of mouse peritoneal macrophages" @default.
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- W2004189965 doi "https://doi.org/10.1016/0378-5173(91)90148-h" @default.
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