FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2004191344> ?p ?o ?g. }

• W2004191344 endingPage "115" @default.
• W2004191344 startingPage "109" @default.
• W2004191344 abstract "This study tested the hypothesis that the expression of CD112 and CD155 (DNAM‐1 ligands) on leukemic blasts induces a decreased expression of the activating receptor DNAM‐1 on natural killer (NK) cells from acute myeloid leukemia (AML) patients. DNAM‐1 is a co‐receptor involved in the activation of NK cell cytotoxicity after its interaction with its ligands CD112 and CD155 on target cells. Here we study the expression of DNAM‐1 on NK cells and DNAM‐1 ligands on blasts from AML patients stratified by age. The results demonstrate that NK cells from AML patients younger than 65 years have a reduced expression of DNAM‐1 compared with age‐matched controls. The analysis of DNAM‐1 ligands showed a high expression of CD112 and CD155 on leukemic blasts. An inverse correlation between CD112 expression on leukemic blasts and DNAM‐1 expression on NK cells was found. Furthermore, downregulation of DNAM‐1 was induced on healthy donors’ NK cells after in vitro culture with leukemic blasts expressing DNAM‐1 ligands. In conclusion, these results support the hypothesis that receptor–ligand crosslinking downregulates DNAM‐1 expression on NK cells from patients <65 years of age. Considering the relevance of DNAM‐1 in NK recognition and killing of leukemic cells, the reduced expression of this receptor on NK cells from AML patients can represent an additional mechanism of tumor escape." @default.
• W2004191344 created "2016-06-24" @default.
• W2004191344 creator A5006515538 @default.
• W2004191344 creator A5011275260 @default.
• W2004191344 creator A5013229327 @default.
• W2004191344 creator A5024647317 @default.
• W2004191344 creator A5031935302 @default.
• W2004191344 creator A5048226255 @default.
• W2004191344 creator A5069030466 @default.
• W2004191344 date "2011-03-08" @default.
• W2004191344 modified "2023-10-01" @default.
• W2004191344 title "Decreased expression of DNAM‐1 on NK cells from acute myeloid leukemia patients" @default.
• W2004191344 cites W1863751964 @default.
• W2004191344 cites W1964982854 @default.
• W2004191344 cites W1972494701 @default.
• W2004191344 cites W1976952965 @default.
• W2004191344 cites W1985331126 @default.
• W2004191344 cites W1993596892 @default.
• W2004191344 cites W1995543512 @default.
• W2004191344 cites W1997849135 @default.
• W2004191344 cites W2000200130 @default.
• W2004191344 cites W2000294762 @default.
• W2004191344 cites W2007825988 @default.
• W2004191344 cites W2018642917 @default.
• W2004191344 cites W2030596005 @default.
• W2004191344 cites W2045836911 @default.
• W2004191344 cites W2052502668 @default.
• W2004191344 cites W2053948715 @default.
• W2004191344 cites W2057625089 @default.
• W2004191344 cites W2058338960 @default.
• W2004191344 cites W2059354338 @default.
• W2004191344 cites W2064706501 @default.
• W2004191344 cites W2074949522 @default.
• W2004191344 cites W2076248543 @default.
• W2004191344 cites W2094790329 @default.
• W2004191344 cites W2099126386 @default.
• W2004191344 cites W2104794630 @default.
• W2004191344 cites W2112574922 @default.
• W2004191344 cites W2118653920 @default.
• W2004191344 cites W2142594520 @default.
• W2004191344 cites W2144201925 @default.
• W2004191344 cites W2144761208 @default.
• W2004191344 cites W2149312162 @default.
• W2004191344 cites W2166197934 @default.
• W2004191344 cites W2168459600 @default.
• W2004191344 cites W4232823847 @default.
• W2004191344 doi "https://doi.org/10.1038/icb.2011.15" @default.
• W2004191344 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21383766" @default.
• W2004191344 hasPublicationYear "2011" @default.
• W2004191344 type Work @default.
• W2004191344 sameAs 2004191344 @default.
• W2004191344 citedByCount "171" @default.
• W2004191344 countsByYear W20041913442012 @default.
• W2004191344 countsByYear W20041913442013 @default.
• W2004191344 countsByYear W20041913442014 @default.
• W2004191344 countsByYear W20041913442015 @default.
• W2004191344 countsByYear W20041913442016 @default.
• W2004191344 countsByYear W20041913442017 @default.
• W2004191344 countsByYear W20041913442018 @default.
• W2004191344 countsByYear W20041913442019 @default.
• W2004191344 countsByYear W20041913442020 @default.
• W2004191344 countsByYear W20041913442021 @default.
• W2004191344 countsByYear W20041913442022 @default.
• W2004191344 countsByYear W20041913442023 @default.
• W2004191344 crossrefType "journal-article" @default.
• W2004191344 hasAuthorship W2004191344A5006515538 @default.
• W2004191344 hasAuthorship W2004191344A5011275260 @default.
• W2004191344 hasAuthorship W2004191344A5013229327 @default.
• W2004191344 hasAuthorship W2004191344A5024647317 @default.
• W2004191344 hasAuthorship W2004191344A5031935302 @default.
• W2004191344 hasAuthorship W2004191344A5048226255 @default.
• W2004191344 hasAuthorship W2004191344A5069030466 @default.
• W2004191344 hasConcept C104317684 @default.
• W2004191344 hasConcept C150194340 @default.
• W2004191344 hasConcept C170493617 @default.
• W2004191344 hasConcept C171122931 @default.
• W2004191344 hasConcept C190727270 @default.
• W2004191344 hasConcept C203014093 @default.
• W2004191344 hasConcept C2775921022 @default.
• W2004191344 hasConcept C2778461978 @default.
• W2004191344 hasConcept C2778729363 @default.
• W2004191344 hasConcept C502942594 @default.
• W2004191344 hasConcept C55493867 @default.
• W2004191344 hasConcept C86803240 @default.
• W2004191344 hasConceptScore W2004191344C104317684 @default.
• W2004191344 hasConceptScore W2004191344C150194340 @default.
• W2004191344 hasConceptScore W2004191344C170493617 @default.
• W2004191344 hasConceptScore W2004191344C171122931 @default.
• W2004191344 hasConceptScore W2004191344C190727270 @default.
• W2004191344 hasConceptScore W2004191344C203014093 @default.
• W2004191344 hasConceptScore W2004191344C2775921022 @default.
• W2004191344 hasConceptScore W2004191344C2778461978 @default.
• W2004191344 hasConceptScore W2004191344C2778729363 @default.
• W2004191344 hasConceptScore W2004191344C502942594 @default.
• W2004191344 hasConceptScore W2004191344C55493867 @default.
• W2004191344 hasConceptScore W2004191344C86803240 @default.
• W2004191344 hasIssue "1" @default.
• W2004191344 hasLocation W20041913441 @default.

• next