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• W2004191360 abstract "Synapse formation requires changes in cell morphology and the upregulation and localization of synaptic proteins. In the cerebellum, mossy fibers undergo extensive remodeling as they contact several granule cells and form complex, multisynaptic glomerular rosettes. Here we show that granule cells secrete factors that induce axon and growth cone remodeling in mossy fibers. This effect is blocked by the WNT antagonist, sFRP-1, and mimicked by WNT-7a, which is expressed by granule cells. WNT-7a also induces synapsin I clustering at remodeled areas of mossy fibers, a preliminary step in synaptogenesis. Wnt-7a mutant mice show a delay in the morphological maturation of glomerular rosettes and in the accumulation of synapsin I. We propose that WNT-7a can function as a synaptogenic factor." @default.
• W2004191360 created "2016-06-24" @default.
• W2004191360 creator A5002858594 @default.
• W2004191360 creator A5020195440 @default.
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• W2004191360 date "2000-03-01" @default.
• W2004191360 modified "2023-10-11" @default.
• W2004191360 title "Axonal Remodeling and Synaptic Differentiation in the Cerebellum Is Regulated by WNT-7a Signaling" @default.
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• W2004191360 doi "https://doi.org/10.1016/s0092-8674(00)80689-3" @default.
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