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• W2004192017 endingPage "299" @default.
• W2004192017 startingPage "289" @default.
• W2004192017 abstract "<h2>Abstract</h2> Clinical response to tamoxifen varies widely among women treated with this drug for hormone receptor-positive breast cancer. The principal active metabolite – endoxifen – is generated through hepatic metabolism of tamoxifen, with key roles for cytochrome P450 (CYP) CYP2D6 and CYP3A. By influencing endoxifen formation, genetic variants of <i>CYP2D6</i> may affect response to tamoxifen. After a decade of research, examining the effects of <i>CYP2D6</i> genetic variants on tamoxifen efficacy, there is still no agreement on the clinical utility of <i>CYP2D6</i> genotype as biomarker for the prediction of breast cancer outcome, because studies revealed conflicting results. However, tamoxifen metabolism is complex and involves several other drug-metabolizing enzymes. Genetic variants of other CYP enzymes, including <i>CYP3A4</i> and <i>CYP2C9/19</i>, as well as co-medication interfering with the metabolic activity of CYP2D6 and CYP3A4 have been shown to affect endoxifen concentrations and may also contribute to the variability in response to tamoxifen. Phenotyping strategies can predict endoxifen exposure more accurately than <i>CYP2D6</i> genotype, but do not take into account all factors influencing endoxifen exposure. Therapeutic drug monitoring (TDM) is likely to be the optimal strategy for individualization of tamoxifen treatment. According to a growing amount of literature, endoxifen concentration seems to be a predictor of clinical outcome. The relationship between endoxifen levels and breast cancer outcomes has to be replicated and confirmed and the value of TDM should be evaluated in prospective clinical trials. Caution is advised regarding the concomitant use of medications which could interact with tamoxifen, including inhibitors and inducers of CYP enzymes." @default.
• W2004192017 created "2016-06-24" @default.
• W2004192017 creator A5008497236 @default.
• W2004192017 creator A5064453966 @default.
• W2004192017 creator A5070750964 @default.
• W2004192017 creator A5074174053 @default.
• W2004192017 date "2015-03-01" @default.
• W2004192017 modified "2023-09-26" @default.
• W2004192017 title "Individualization of tamoxifen therapy: Much more than just CYP2D6 genotyping" @default.
• W2004192017 cites W1508284217 @default.
• W2004192017 cites W1595502980 @default.
• W2004192017 cites W1631027698 @default.
• W2004192017 cites W1846683971 @default.
• W2004192017 cites W1864994387 @default.
• W2004192017 cites W1961026612 @default.
• W2004192017 cites W1965550166 @default.
• W2004192017 cites W1966355764 @default.
• W2004192017 cites W1966590360 @default.
• W2004192017 cites W1968591698 @default.
• W2004192017 cites W1970531647 @default.
• W2004192017 cites W1976578059 @default.
• W2004192017 cites W1984806865 @default.
• W2004192017 cites W1985380895 @default.
• W2004192017 cites W1986685858 @default.
• W2004192017 cites W1987126382 @default.
• W2004192017 cites W1987753117 @default.
• W2004192017 cites W1993465290 @default.
• W2004192017 cites W1997530992 @default.
• W2004192017 cites W1997796143 @default.
• W2004192017 cites W1999611235 @default.
• W2004192017 cites W2001333277 @default.
• W2004192017 cites W2008825099 @default.
• W2004192017 cites W2009439253 @default.
• W2004192017 cites W2011257422 @default.
• W2004192017 cites W2013479777 @default.
• W2004192017 cites W2015092588 @default.
• W2004192017 cites W2026378497 @default.
• W2004192017 cites W2029549183 @default.
• W2004192017 cites W2034897616 @default.
• W2004192017 cites W2035752885 @default.
• W2004192017 cites W2039650615 @default.
• W2004192017 cites W2042168497 @default.
• W2004192017 cites W2044308633 @default.
• W2004192017 cites W2045654730 @default.
• W2004192017 cites W2046248898 @default.
• W2004192017 cites W2047246104 @default.
• W2004192017 cites W2047262134 @default.
• W2004192017 cites W2047503441 @default.
• W2004192017 cites W2055560401 @default.
• W2004192017 cites W2057776142 @default.
• W2004192017 cites W2063345843 @default.
• W2004192017 cites W2069648734 @default.
• W2004192017 cites W2071185486 @default.
• W2004192017 cites W2071265080 @default.
• W2004192017 cites W2076734790 @default.
• W2004192017 cites W2076741971 @default.
• W2004192017 cites W2078280339 @default.
• W2004192017 cites W2079689268 @default.
• W2004192017 cites W2080228333 @default.
• W2004192017 cites W2082048952 @default.
• W2004192017 cites W2097006862 @default.
• W2004192017 cites W2101386343 @default.
• W2004192017 cites W2103550433 @default.
• W2004192017 cites W2104019649 @default.
• W2004192017 cites W2104047469 @default.
• W2004192017 cites W2104708747 @default.
• W2004192017 cites W2104775804 @default.
• W2004192017 cites W2111738175 @default.
• W2004192017 cites W2117605200 @default.
• W2004192017 cites W2118728607 @default.
• W2004192017 cites W2120384798 @default.
• W2004192017 cites W2120981370 @default.
• W2004192017 cites W2122090386 @default.
• W2004192017 cites W2127660956 @default.
• W2004192017 cites W2130377362 @default.
• W2004192017 cites W2132843748 @default.
• W2004192017 cites W2133468550 @default.
• W2004192017 cites W2135502243 @default.
• W2004192017 cites W2137490350 @default.
• W2004192017 cites W2137925405 @default.
• W2004192017 cites W2141551056 @default.
• W2004192017 cites W2143259335 @default.
• W2004192017 cites W2146902715 @default.
• W2004192017 cites W2147099166 @default.
• W2004192017 cites W2147225212 @default.
• W2004192017 cites W2151206172 @default.
• W2004192017 cites W2151308400 @default.
• W2004192017 cites W2151950513 @default.
• W2004192017 cites W2154067964 @default.
• W2004192017 cites W2154444846 @default.
• W2004192017 cites W2158288355 @default.
• W2004192017 cites W2158973032 @default.
• W2004192017 cites W2160074846 @default.
• W2004192017 cites W2162625234 @default.
• W2004192017 cites W2162784517 @default.
• W2004192017 cites W2163402413 @default.
• W2004192017 cites W2167065216 @default.
• W2004192017 cites W2167100085 @default.

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