FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2004195610> ?p ?o ?g. }

• W2004195610 endingPage "576" @default.
• W2004195610 startingPage "566" @default.
• W2004195610 abstract "Dementia of the Alzheimer type (AD) is clinically characterized by a progressive deterioration of intellect, memory, judgment, and abstract thinking. It is incurable, and causal therapy is not yet available. For the development of therapeutic drugs, valid animal models are needed that mimic the pathophysiological change in brain functions and the concomitant behavioural deterioration seen in AD patients. This article provides an overview of the animal models that are used most often to study the substrates and mechanisms of the pathological changes underlying AD and to identify, characterize and develop putative neuroprotective, antidegenerative, revalidation-supporting and/or cognition-enhancing compounds or treatments. The first generation of agents for the symptomatic treatment of the disease has been developed on the basis of results obtained with these models. These drugs are presently undergoing clinical testing or are already used therapeutically. There is, however, no single animal model that can mimic the full range of pathophysiological alterations and key symptoms of AD. New, genetically engineered mouse models that mimic at least some of the key pathological changes of AD are expected to provide tools that will facilitate the development of symptomatic and preventive drug therapies." @default.
• W2004195610 created "2016-06-24" @default.
• W2004195610 creator A5022063104 @default.
• W2004195610 creator A5029878817 @default.
• W2004195610 creator A5091796281 @default.
• W2004195610 date "1998-01-01" @default.
• W2004195610 modified "2023-09-27" @default.
• W2004195610 title "Animal models in the development of symptomatic and preventive drug therapies for Alzheimer's disease" @default.
• W2004195610 cites W1602004204 @default.
• W2004195610 cites W1969746914 @default.
• W2004195610 cites W1974130870 @default.
• W2004195610 cites W1977683347 @default.
• W2004195610 cites W1979432217 @default.
• W2004195610 cites W1980239800 @default.
• W2004195610 cites W1983021005 @default.
• W2004195610 cites W1988757966 @default.
• W2004195610 cites W1995348578 @default.
• W2004195610 cites W1999161402 @default.
• W2004195610 cites W2001210466 @default.
• W2004195610 cites W2004713321 @default.
• W2004195610 cites W2019329567 @default.
• W2004195610 cites W2021280501 @default.
• W2004195610 cites W2028201381 @default.
• W2004195610 cites W2034005299 @default.
• W2004195610 cites W2034716956 @default.
• W2004195610 cites W2048449891 @default.
• W2004195610 cites W2048464861 @default.
• W2004195610 cites W2049144486 @default.
• W2004195610 cites W2050856560 @default.
• W2004195610 cites W2056633785 @default.
• W2004195610 cites W2056994786 @default.
• W2004195610 cites W2062706679 @default.
• W2004195610 cites W2069566607 @default.
• W2004195610 cites W2071029530 @default.
• W2004195610 cites W2072225960 @default.
• W2004195610 cites W2077464099 @default.
• W2004195610 cites W2081998222 @default.
• W2004195610 cites W2083266418 @default.
• W2004195610 cites W2084177469 @default.
• W2004195610 cites W2084997223 @default.
• W2004195610 cites W2085823254 @default.
• W2004195610 cites W2095745901 @default.
• W2004195610 cites W2116155138 @default.
• W2004195610 cites W2126800086 @default.
• W2004195610 cites W2151860032 @default.
• W2004195610 cites W2152185487 @default.
• W2004195610 cites W2333081045 @default.
• W2004195610 cites W4211192748 @default.
• W2004195610 cites W4230636610 @default.
• W2004195610 doi "https://doi.org/10.3109/07853899809002606" @default.
• W2004195610 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9920360" @default.
• W2004195610 hasPublicationYear "1998" @default.
• W2004195610 type Work @default.
• W2004195610 sameAs 2004195610 @default.
• W2004195610 citedByCount "14" @default.
• W2004195610 crossrefType "journal-article" @default.
• W2004195610 hasAuthorship W2004195610A5022063104 @default.
• W2004195610 hasAuthorship W2004195610A5029878817 @default.
• W2004195610 hasAuthorship W2004195610A5091796281 @default.
• W2004195610 hasConcept C126322002 @default.
• W2004195610 hasConcept C142724271 @default.
• W2004195610 hasConcept C15744967 @default.
• W2004195610 hasConcept C169760540 @default.
• W2004195610 hasConcept C177713679 @default.
• W2004195610 hasConcept C207886595 @default.
• W2004195610 hasConcept C25498285 @default.
• W2004195610 hasConcept C2778117688 @default.
• W2004195610 hasConcept C2779134260 @default.
• W2004195610 hasConcept C2779483572 @default.
• W2004195610 hasConcept C2780035454 @default.
• W2004195610 hasConcept C502032728 @default.
• W2004195610 hasConcept C60644358 @default.
• W2004195610 hasConcept C64903051 @default.
• W2004195610 hasConcept C71924100 @default.
• W2004195610 hasConcept C86803240 @default.
• W2004195610 hasConcept C98274493 @default.
• W2004195610 hasConceptScore W2004195610C126322002 @default.
• W2004195610 hasConceptScore W2004195610C142724271 @default.
• W2004195610 hasConceptScore W2004195610C15744967 @default.
• W2004195610 hasConceptScore W2004195610C169760540 @default.
• W2004195610 hasConceptScore W2004195610C177713679 @default.
• W2004195610 hasConceptScore W2004195610C207886595 @default.
• W2004195610 hasConceptScore W2004195610C25498285 @default.
• W2004195610 hasConceptScore W2004195610C2778117688 @default.
• W2004195610 hasConceptScore W2004195610C2779134260 @default.
• W2004195610 hasConceptScore W2004195610C2779483572 @default.
• W2004195610 hasConceptScore W2004195610C2780035454 @default.
• W2004195610 hasConceptScore W2004195610C502032728 @default.
• W2004195610 hasConceptScore W2004195610C60644358 @default.
• W2004195610 hasConceptScore W2004195610C64903051 @default.
• W2004195610 hasConceptScore W2004195610C71924100 @default.
• W2004195610 hasConceptScore W2004195610C86803240 @default.
• W2004195610 hasConceptScore W2004195610C98274493 @default.
• W2004195610 hasIssue "6" @default.
• W2004195610 hasLocation W20041956101 @default.
• W2004195610 hasLocation W20041956102 @default.
• W2004195610 hasOpenAccess W2004195610 @default.
• W2004195610 hasPrimaryLocation W20041956101 @default.

• next