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- W2004196985 abstract "To the Editor.— In the May 5, 1989, issue of JAMA , Drs Wyllie, Pippenger, and Rothner 1 were castigated by Nightingale et al of the Food and Drug Administration, 2 Robert Shulman of the Bolar Pharmaceutical Company, 2 and by the Deputy Editor (West) of JAMA . 3 This rather harsh criticism followed the article by Wyllie et al in which a patient was described with a static encephalopathy and a seizure disorder. During an October 1985 hospital admission her seizures were under reasonable control with a combination of Klonopin and Mysoline (500 mg/d) with a blood level for primidone of 10.8 mg/L. She then began experiencing increased seizure activity with a drop in her primidone level to 5.1 mg/L and subsequently to 2.0 mg/L despite a dosage increase. The reason for the drop in her level was ultimately found to have been secondary to generic primidone substituted for Mysoline by" @default.
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- W2004196985 date "1990-07-04" @default.
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- W2004196985 title "The Role of Data Audits in Detecting Scientific Misconduct" @default.
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- W2004196985 doi "https://doi.org/10.1001/jama.1990.03450010039021" @default.
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