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• W2004198397 abstract "Cerebral palsy is caused by injury or developmental disturbances to the immature brain and leads to substantial motor, cognitive, and learning deficits. In addition to developmental disruption associated with the initial insult to the immature brain, injury processes can persist for many months or years. We suggest that these tertiary mechanisms of damage might include persistent inflammation and epigenetic changes. We propose that these processes are implicit in prevention of endogenous repair and regeneration and predispose patients to development of future cognitive dysfunction and sensitisation to further injury. We suggest that treatment of tertiary mechanisms of damage might be possible by various means, including preventing the repressive effects of microglia and astrocyte over-activation, recapitulating developmentally permissive epigenetic conditions, and using cell therapies to stimulate repair and regeneration Recognition of tertiary mechanisms of damage might be the first step in a complex translational task to tailor safe and effective therapies that can be used to treat the already developmentally disrupted brain long after an insult. Cerebral palsy is caused by injury or developmental disturbances to the immature brain and leads to substantial motor, cognitive, and learning deficits. In addition to developmental disruption associated with the initial insult to the immature brain, injury processes can persist for many months or years. We suggest that these tertiary mechanisms of damage might include persistent inflammation and epigenetic changes. We propose that these processes are implicit in prevention of endogenous repair and regeneration and predispose patients to development of future cognitive dysfunction and sensitisation to further injury. We suggest that treatment of tertiary mechanisms of damage might be possible by various means, including preventing the repressive effects of microglia and astrocyte over-activation, recapitulating developmentally permissive epigenetic conditions, and using cell therapies to stimulate repair and regeneration Recognition of tertiary mechanisms of damage might be the first step in a complex translational task to tailor safe and effective therapies that can be used to treat the already developmentally disrupted brain long after an insult. Pierre Gressens: pioneer of perinatal neurosciencePierre Gressens is a man preoccupied with time, and not only because he spends so much of it on the Eurostar zooming between his Paris base at the Diderot University and Robert-Debré Hospital and his office in the Hammersmith Hospital, London, UK. As a leader in developmental neuroscience who, according to Washington University's Terrie Inder has made “unparalleled contributions to our understanding of the pathogenesis of injury to the immature brain”, time is an absolutely crucial factor for Gressens “because the developing brain is really moving all the time”, he explains. Full-Text PDF" @default.
• W2004198397 created "2016-06-24" @default.
• W2004198397 creator A5033474449 @default.
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• W2004198397 date "2012-06-01" @default.
• W2004198397 modified "2023-10-10" @default.
• W2004198397 title "Tertiary mechanisms of brain damage: a new hope for treatment of cerebral palsy?" @default.
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