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- W200419946 abstract "Second-generation metal-on-metal (M/M) total hip replacements were introduced into clinical use in the late 1980s and demonstrate equivalent survivorship to conventional metal-on-polyethylene prostheses. Wear rates are comparable to those of first-generation designs that survived for a long time in the body. Biological effects from metal ions remain a concern. Patients with both first- and second-generation M/M hips have higher levels of cobalt and chromium in their blood and urine than either patients with metal-on-polyethylene devices or unoperated patients. Concerns include the potential for acquired hypersensitivity, mutagenicity, and carcinogenicity. However, reports of proven adverse effects are scant. Prospective, randomized trials with follow-up in excess of 15 years will be needed to differentiate between the performance and effects of M/M and other bearing combinations. Key words: totalhip arthroplasty, metal-on-metal, wear, biological effects, clinical results." @default.
- W200419946 created "2016-06-24" @default.
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- W200419946 date "2005-02-01" @default.
- W200419946 modified "2023-09-27" @default.
- W200419946 title "Metal-on-Metal Total Hip Replacement" @default.
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- W200419946 doi "https://doi.org/10.1016/j.arth.2004.08.011" @default.
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