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• W2004200740 abstract "In Brief Purpose: To investigate the effect of photodynamic therapy (PDT) with verteporfin on patients with vitelliform lesions caused by cuticular drusen or adult-onset foveomacular vitelliform dystrophy (AOFVD). Design: Observational case series. Patients and Methods: Eight eyes of seven patients from two centers were examined prospectively. Each patient received PDT with verteporfin applied to the vitelliform lesions. Results: Photodynamic therapy did not significantly affect the median visual acuity outcome (20/50 before PDT and 20/66 after PDT) in all seven treated patients. Of note, however, were four eyes of four patients who experienced a severe decrease in visual acuity after PDT with verteporfin. The temporary relationship of the vision loss to the treatment suggests that this may represent an adverse effect from therapy. The fluorescein angiographic appearance was virtually unchanged in all treated patients, whereas indocyanine green angiography showed typical PDT-associated reduction of choroidal perfusion in the treatment area. Conclusion: Photodynamic therapy does not have a positive influence on the visual outcome in patients with vitelliform lesions and may have a negative impact on vision in some treated patients. It is important for physicians using PDT to exercise caution in distinguishing between choroidal neovascular membranes and vitelliform lesions because the outcome in this latter group may be worse with application of PDT than with the natural course. PDT does not have a positive influence on the visual outcome in patients with vitelliform lesions and may have a negative impact on vision in some treated patients. It is important for physicians utilizing PDT to exercise caution in distinguishing between choroidal neovascularization membranes and vitelliform lesions in that the outcome in this latter group may be worse with application of PDT than with the natural course." @default.
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• W2004200740 date "2004-06-01" @default.
• W2004200740 modified "2023-09-25" @default.
• W2004200740 title "PHOTODYNAMIC THERAPY AND VITELLIFORM LESIONS" @default.
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• W2004200740 doi "https://doi.org/10.1097/00006982-200406000-00010" @default.
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