FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2004203209> ?p ?o ?g. }

• W2004203209 endingPage "830" @default.
• W2004203209 startingPage "823" @default.
• W2004203209 abstract "The molecular genetic events underlying thyroid carcinogenesis are not well understood. Mice harboring a dominant-negative mutant thyroid hormone receptor-beta (TRbeta(PV/PV) mice) spontaneously develop follicular thyroid carcinoma similar to human cancer. The present study aimed to elucidate the role of the steroid receptor coactivator-3 (SRC-3) in thyroid carcinogenesis in vivo by using the offspring from the cross of TRbeta(PV/PV) and SRC-3(-/-) mice. TRbeta(PV/PV) mice deficient in SRC-3 (TRbeta(PV/PV)SRC-3(-/-) mice) had significantly increased survival, decreased thyroid tumor growth, delayed tumor progression and lower incidence of distant metastasis as compared with TRbeta(PV/PV) mice with SRC-3 (TRbeta(PV/PV)SRC-3(+/+) mice). Further, in vivo and in vitro analyses of multiple signaling pathways indicated that SRC-3 deficiency could lead to (1) inhibition of cell cycle progression at the G(1)/S transition via controlling the expression of cell cycle regulators, such as E2F1; (2) induction of apoptosis by controlling the expression of the Bcl-2 and caspase-3 genes and (3) suppression of neovascularization and metastasis, at least in part, through modulating the vascular endothelial growth factor gene expression. Taken together, SRC-3 could play important roles through regulating multiple target genes and signaling pathways during thyroid carcinogenesis, understanding of which should direct future therapeutic options for thyroid cancer." @default.
• W2004203209 created "2016-06-24" @default.
• W2004203209 creator A5016960224 @default.
• W2004203209 creator A5036373667 @default.
• W2004203209 creator A5053186275 @default.
• W2004203209 date "2007-07-23" @default.
• W2004203209 modified "2023-10-18" @default.
• W2004203209 title "The steroid receptor coactivator-3 is a tumor promoter in a mouse model of thyroid cancer" @default.
• W2004203209 cites W1922704711 @default.
• W2004203209 cites W1967468131 @default.
• W2004203209 cites W1988889506 @default.
• W2004203209 cites W2004357951 @default.
• W2004203209 cites W2005091899 @default.
• W2004203209 cites W2007213945 @default.
• W2004203209 cites W2037785445 @default.
• W2004203209 cites W2052460272 @default.
• W2004203209 cites W2060128629 @default.
• W2004203209 cites W2064956340 @default.
• W2004203209 cites W2079149091 @default.
• W2004203209 cites W2080662424 @default.
• W2004203209 cites W2097134216 @default.
• W2004203209 cites W2103890277 @default.
• W2004203209 cites W2104200252 @default.
• W2004203209 cites W2135958288 @default.
• W2004203209 cites W2141059705 @default.
• W2004203209 cites W2143745813 @default.
• W2004203209 cites W2152459272 @default.
• W2004203209 cites W2156651282 @default.
• W2004203209 cites W2167787018 @default.
• W2004203209 cites W4247050062 @default.
• W2004203209 doi "https://doi.org/10.1038/sj.onc.1210680" @default.
• W2004203209 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17653082" @default.
• W2004203209 hasPublicationYear "2007" @default.
• W2004203209 type Work @default.
• W2004203209 sameAs 2004203209 @default.
• W2004203209 citedByCount "27" @default.
• W2004203209 countsByYear W20042032092012 @default.
• W2004203209 countsByYear W20042032092013 @default.
• W2004203209 countsByYear W20042032092014 @default.
• W2004203209 countsByYear W20042032092016 @default.
• W2004203209 countsByYear W20042032092017 @default.
• W2004203209 countsByYear W20042032092018 @default.
• W2004203209 countsByYear W20042032092020 @default.
• W2004203209 countsByYear W20042032092021 @default.
• W2004203209 countsByYear W20042032092023 @default.
• W2004203209 crossrefType "journal-article" @default.
• W2004203209 hasAuthorship W2004203209A5016960224 @default.
• W2004203209 hasAuthorship W2004203209A5036373667 @default.
• W2004203209 hasAuthorship W2004203209A5053186275 @default.
• W2004203209 hasBestOaLocation W20042032091 @default.
• W2004203209 hasConcept C109115496 @default.
• W2004203209 hasConcept C121608353 @default.
• W2004203209 hasConcept C126322002 @default.
• W2004203209 hasConcept C134018914 @default.
• W2004203209 hasConcept C137620995 @default.
• W2004203209 hasConcept C2779013556 @default.
• W2004203209 hasConcept C2779341817 @default.
• W2004203209 hasConcept C2779761222 @default.
• W2004203209 hasConcept C2781461381 @default.
• W2004203209 hasConcept C2993294228 @default.
• W2004203209 hasConcept C502942594 @default.
• W2004203209 hasConcept C526584372 @default.
• W2004203209 hasConcept C54355233 @default.
• W2004203209 hasConcept C555283112 @default.
• W2004203209 hasConcept C62478195 @default.
• W2004203209 hasConcept C71924100 @default.
• W2004203209 hasConcept C86803240 @default.
• W2004203209 hasConcept C95444343 @default.
• W2004203209 hasConceptScore W2004203209C109115496 @default.
• W2004203209 hasConceptScore W2004203209C121608353 @default.
• W2004203209 hasConceptScore W2004203209C126322002 @default.
• W2004203209 hasConceptScore W2004203209C134018914 @default.
• W2004203209 hasConceptScore W2004203209C137620995 @default.
• W2004203209 hasConceptScore W2004203209C2779013556 @default.
• W2004203209 hasConceptScore W2004203209C2779341817 @default.
• W2004203209 hasConceptScore W2004203209C2779761222 @default.
• W2004203209 hasConceptScore W2004203209C2781461381 @default.
• W2004203209 hasConceptScore W2004203209C2993294228 @default.
• W2004203209 hasConceptScore W2004203209C502942594 @default.
• W2004203209 hasConceptScore W2004203209C526584372 @default.
• W2004203209 hasConceptScore W2004203209C54355233 @default.
• W2004203209 hasConceptScore W2004203209C555283112 @default.
• W2004203209 hasConceptScore W2004203209C62478195 @default.
• W2004203209 hasConceptScore W2004203209C71924100 @default.
• W2004203209 hasConceptScore W2004203209C86803240 @default.
• W2004203209 hasConceptScore W2004203209C95444343 @default.
• W2004203209 hasIssue "6" @default.
• W2004203209 hasLocation W20042032091 @default.
• W2004203209 hasLocation W20042032092 @default.
• W2004203209 hasOpenAccess W2004203209 @default.
• W2004203209 hasPrimaryLocation W20042032091 @default.
• W2004203209 hasRelatedWork W1499339123 @default.
• W2004203209 hasRelatedWork W2015707644 @default.
• W2004203209 hasRelatedWork W2026158761 @default.
• W2004203209 hasRelatedWork W2027475709 @default.
• W2004203209 hasRelatedWork W2092628191 @default.
• W2004203209 hasRelatedWork W2096799980 @default.
• W2004203209 hasRelatedWork W2763237291 @default.

• next