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• W2004203943 abstract "4-Methyl-5-β-hydroxyethylthiazole kinase (ThiK) catalyses the phosphorylation of the hydroxyl group of 4-methyl-5-β-hydroxyethylthiazole. This work reports the first crystal structure of an archaeal ThiK: that from Pyrococcus horikoshii OT3 (PhThiK) at 1.85 Å resolution with a phosphate ion occupying the position of the β-phosphate of the nucleotide. The topology of this enzyme shows the typical ribokinase fold of an α/β protein. The overall structure of PhThiK is similar to those of Bacillus subtilis ThiK (BsThiK) and Enterococcus faecalis V583 ThiK (EfThiK). Sequence analysis of ThiK enzymes from various sources indicated that three-quarters of the residues involved in interfacial regions are conserved. It also revealed that the amino-acid residues in the nucleotide-binding, magnesium ion-binding and substrate-binding sites are conserved. Binding of the nucleotide and substrate to the ThiK enzyme do not influence the quaternary association (trimer) as revealed by the crystal structure of PhThiK." @default.
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• W2004203943 date "2009-09-18" @default.
• W2004203943 modified "2023-10-01" @default.
• W2004203943 title "New structural insights and molecular-modelling studies of 4-methyl-5-β-hydroxyethylthiazole kinase from<i>Pyrococcus horikoshii</i>OT3 (<i>Ph</i>ThiK)" @default.
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• W2004203943 doi "https://doi.org/10.1107/s1744309109036033" @default.
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