FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2004205172> ?p ?o ?g. }

• W2004205172 endingPage "186" @default.
• W2004205172 startingPage "181" @default.
• W2004205172 abstract "Estrogen receptor negative (ER−ve) and p53 mutant breast tumors are highly aggressive and have fewer treatment options. Previously, we showed that molecular Iodine (I2) induces apoptosis in hormone responsive MCF-7 breast cancer cells, and non-apoptotic cell death in ER−ve–p53 mutant MDA-MB231 cells (Shrivastava, 2006). Here we show that I2 (3 μM) treatment enhanced the features of autophagy in MDA-MB231 cells. Since autophagy is a cell survival response to most anti-cancer therapies, we used both in vitro and in vivo systems to determine whether ER−ve mammary tumors could be sensitized to I2-induced apoptosis by inhibiting autophagy. Autophagy inhibition with chloroquine (CQ) and inhibitors for PI3K (3MA, LY294002) and H+/ATPase (baflomycin) resulted in enhanced cell death in I2 treated MDA-MB231 cells. Further, CQ (20 μM) in combination with I2, showed apoptotic features such as increased sub-G1 fraction (∼5-fold), expression of cleaved caspase-9 and -3 compared to I2 treatment alone. Flowcytometry of I2 and CQ co-treated cells revealed increase in mitochondrial membrane permeability (p < 0.01) and translocation of cathepsin D activity to cytosol relative to I2 treatment. For in vivo studies ICRC mice were transplanted subcutaneously with MMTV-induced mammary tumors. A significant reduction in tumor volumes, as measured by MRI, was found in I2 and CQ co-treated mice relative to I2 or vehicle treated mice. These data indicate that inhibition of autophagy renders ER−ve breast tumor cells more sensitive to I2 induced apoptosis. Thus, I2 together with autophagy inhibitor could have a potential tumorostatic role in ER−ve aggressive breast tumors that may be evaluated in future studies." @default.
• W2004205172 created "2016-06-24" @default.
• W2004205172 creator A5002313374 @default.
• W2004205172 creator A5016797401 @default.
• W2004205172 creator A5031935309 @default.
• W2004205172 creator A5042389038 @default.
• W2004205172 creator A5042672044 @default.
• W2004205172 creator A5051194722 @default.
• W2004205172 creator A5078763030 @default.
• W2004205172 creator A5083553484 @default.
• W2004205172 creator A5084618028 @default.
• W2004205172 date "2011-11-01" @default.
• W2004205172 modified "2023-09-27" @default.
• W2004205172 title "Inhibition of autophagy stimulate molecular iodine-induced apoptosis in hormone independent breast tumors" @default.
• W2004205172 cites W1968720144 @default.
• W2004205172 cites W1972336737 @default.
• W2004205172 cites W1972612572 @default.
• W2004205172 cites W1993643473 @default.
• W2004205172 cites W1994594485 @default.
• W2004205172 cites W2011165415 @default.
• W2004205172 cites W2031727967 @default.
• W2004205172 cites W2051945714 @default.
• W2004205172 cites W2059200921 @default.
• W2004205172 cites W2097638181 @default.
• W2004205172 cites W2104282171 @default.
• W2004205172 cites W2106255061 @default.
• W2004205172 cites W2112987361 @default.
• W2004205172 cites W2157699677 @default.
• W2004205172 cites W2159696390 @default.
• W2004205172 cites W2172201532 @default.
• W2004205172 doi "https://doi.org/10.1016/j.bbrc.2011.10.054" @default.
• W2004205172 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22027149" @default.
• W2004205172 hasPublicationYear "2011" @default.
• W2004205172 type Work @default.
• W2004205172 sameAs 2004205172 @default.
• W2004205172 citedByCount "27" @default.
• W2004205172 countsByYear W20042051722012 @default.
• W2004205172 countsByYear W20042051722013 @default.
• W2004205172 countsByYear W20042051722014 @default.
• W2004205172 countsByYear W20042051722015 @default.
• W2004205172 countsByYear W20042051722016 @default.
• W2004205172 countsByYear W20042051722017 @default.
• W2004205172 countsByYear W20042051722018 @default.
• W2004205172 countsByYear W20042051722019 @default.
• W2004205172 countsByYear W20042051722020 @default.
• W2004205172 countsByYear W20042051722021 @default.
• W2004205172 countsByYear W20042051722022 @default.
• W2004205172 crossrefType "journal-article" @default.
• W2004205172 hasAuthorship W2004205172A5002313374 @default.
• W2004205172 hasAuthorship W2004205172A5016797401 @default.
• W2004205172 hasAuthorship W2004205172A5031935309 @default.
• W2004205172 hasAuthorship W2004205172A5042389038 @default.
• W2004205172 hasAuthorship W2004205172A5042672044 @default.
• W2004205172 hasAuthorship W2004205172A5051194722 @default.
• W2004205172 hasAuthorship W2004205172A5078763030 @default.
• W2004205172 hasAuthorship W2004205172A5083553484 @default.
• W2004205172 hasAuthorship W2004205172A5084618028 @default.
• W2004205172 hasConcept C121608353 @default.
• W2004205172 hasConcept C126322002 @default.
• W2004205172 hasConcept C150903083 @default.
• W2004205172 hasConcept C173633252 @default.
• W2004205172 hasConcept C181199279 @default.
• W2004205172 hasConcept C185592680 @default.
• W2004205172 hasConcept C190283241 @default.
• W2004205172 hasConcept C203522944 @default.
• W2004205172 hasConcept C207001950 @default.
• W2004205172 hasConcept C28021979 @default.
• W2004205172 hasConcept C31573885 @default.
• W2004205172 hasConcept C502942594 @default.
• W2004205172 hasConcept C530470458 @default.
• W2004205172 hasConcept C55493867 @default.
• W2004205172 hasConcept C71924100 @default.
• W2004205172 hasConcept C84606932 @default.
• W2004205172 hasConcept C86554907 @default.
• W2004205172 hasConcept C86803240 @default.
• W2004205172 hasConceptScore W2004205172C121608353 @default.
• W2004205172 hasConceptScore W2004205172C126322002 @default.
• W2004205172 hasConceptScore W2004205172C150903083 @default.
• W2004205172 hasConceptScore W2004205172C173633252 @default.
• W2004205172 hasConceptScore W2004205172C181199279 @default.
• W2004205172 hasConceptScore W2004205172C185592680 @default.
• W2004205172 hasConceptScore W2004205172C190283241 @default.
• W2004205172 hasConceptScore W2004205172C203522944 @default.
• W2004205172 hasConceptScore W2004205172C207001950 @default.
• W2004205172 hasConceptScore W2004205172C28021979 @default.
• W2004205172 hasConceptScore W2004205172C31573885 @default.
• W2004205172 hasConceptScore W2004205172C502942594 @default.
• W2004205172 hasConceptScore W2004205172C530470458 @default.
• W2004205172 hasConceptScore W2004205172C55493867 @default.
• W2004205172 hasConceptScore W2004205172C71924100 @default.
• W2004205172 hasConceptScore W2004205172C84606932 @default.
• W2004205172 hasConceptScore W2004205172C86554907 @default.
• W2004205172 hasConceptScore W2004205172C86803240 @default.
• W2004205172 hasIssue "1" @default.
• W2004205172 hasLocation W20042051721 @default.
• W2004205172 hasLocation W20042051722 @default.
• W2004205172 hasOpenAccess W2004205172 @default.
• W2004205172 hasPrimaryLocation W20042051721 @default.

• next