FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2004207671> ?p ?o ?g. }

• W2004207671 endingPage "784" @default.
• W2004207671 startingPage "777" @default.
• W2004207671 abstract "Phosphatidylethanolamine N-methylation was examined in cardiac subcellular membranes after inducing chronic experimental diabetes in rats (65 mg streptozotocin/kg, i.v.). The incorporation of radiolabeled methyl groups from S-adenosyl-L-methionine in diabetic sarcolemma was significantly depressed at all three catalytic sites (I, II, and III) of the methyltransferase system. An increase in methyl group incorporation was evident at site I without any changes at sites II and III in diabetic sarcoplasmic reticulum and mitochondria. Similar changes were also seen for the individual N-methylated lipids (monomethyl-, dimethylphosphatidylethanolamine, and phosphatidylcholine) specifically formed at each catalytic site in all cardiac membranes from diabetic animals. These alterations in N-methylation were reversible by a 14-d insulin therapy to the diabetic animals. In the presence of 10 microM ATP and 0.1 microM Ca2+, N-methylation was maximally activated at site I in both control and diabetic sarcolemma and sarcoplasmic reticulum, but not in mitochondria. Incubation of cardiac membranes with of S-adenosyl-L-methionine showed that Ca2(+)-stimulated ATPase activities in both sarcolemma and sarcoplasmic reticulum were augmented; however, the activation of diabetic sarcolemma was lesser and that of diabetic sarcoplasmic reticulum was greater in comparison with the control preparations. These results identify alterations in phosphatidylethanolamine N-methylation in subcellular membranes from diabetic heart, and it is suggested that these defects may be crucial in the development of cardiac dysfunction in chronic diabetes." @default.
• W2004207671 created "2016-06-24" @default.
• W2004207671 creator A5011896624 @default.
• W2004207671 creator A5038178064 @default.
• W2004207671 creator A5054074625 @default.
• W2004207671 creator A5067016118 @default.
• W2004207671 creator A5068857226 @default.
• W2004207671 date "1990-09-01" @default.
• W2004207671 modified "2023-09-30" @default.
• W2004207671 title "Alterations in phospholipid N-methylation of cardiac subcellular membranes due to experimentally induced diabetes in rats." @default.
• W2004207671 cites W1539399265 @default.
• W2004207671 cites W1598898722 @default.
• W2004207671 cites W1966491895 @default.
• W2004207671 cites W1978735297 @default.
• W2004207671 cites W1982602193 @default.
• W2004207671 cites W1987069814 @default.
• W2004207671 cites W1988317051 @default.
• W2004207671 cites W2002886374 @default.
• W2004207671 cites W2015593078 @default.
• W2004207671 cites W2034593593 @default.
• W2004207671 cites W2043477672 @default.
• W2004207671 cites W2044020948 @default.
• W2004207671 cites W2052593443 @default.
• W2004207671 cites W2055785067 @default.
• W2004207671 cites W2061223589 @default.
• W2004207671 cites W2072117124 @default.
• W2004207671 cites W2090961905 @default.
• W2004207671 cites W2122850211 @default.
• W2004207671 cites W2124342575 @default.
• W2004207671 cites W2148076373 @default.
• W2004207671 cites W2182387002 @default.
• W2004207671 cites W2182965704 @default.
• W2004207671 cites W2399561814 @default.
• W2004207671 cites W2410121300 @default.
• W2004207671 cites W2462757309 @default.
• W2004207671 cites W2469367375 @default.
• W2004207671 cites W42206112 @default.
• W2004207671 doi "https://doi.org/10.1172/jci114774" @default.
• W2004207671 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/296792" @default.
• W2004207671 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2144301" @default.
• W2004207671 hasPublicationYear "1990" @default.
• W2004207671 type Work @default.
• W2004207671 sameAs 2004207671 @default.
• W2004207671 citedByCount "34" @default.
• W2004207671 countsByYear W20042076712013 @default.
• W2004207671 countsByYear W20042076712016 @default.
• W2004207671 countsByYear W20042076712017 @default.
• W2004207671 countsByYear W20042076712023 @default.
• W2004207671 crossrefType "journal-article" @default.
• W2004207671 hasAuthorship W2004207671A5011896624 @default.
• W2004207671 hasAuthorship W2004207671A5038178064 @default.
• W2004207671 hasAuthorship W2004207671A5054074625 @default.
• W2004207671 hasAuthorship W2004207671A5067016118 @default.
• W2004207671 hasAuthorship W2004207671A5068857226 @default.
• W2004207671 hasBestOaLocation W20042076711 @default.
• W2004207671 hasConcept C104317684 @default.
• W2004207671 hasConcept C126322002 @default.
• W2004207671 hasConcept C134018914 @default.
• W2004207671 hasConcept C158617107 @default.
• W2004207671 hasConcept C185592680 @default.
• W2004207671 hasConcept C199096232 @default.
• W2004207671 hasConcept C2776330855 @default.
• W2004207671 hasConcept C2778918659 @default.
• W2004207671 hasConcept C2779280383 @default.
• W2004207671 hasConcept C2779959927 @default.
• W2004207671 hasConcept C2781170229 @default.
• W2004207671 hasConcept C33288867 @default.
• W2004207671 hasConcept C41625074 @default.
• W2004207671 hasConcept C55493867 @default.
• W2004207671 hasConcept C555293320 @default.
• W2004207671 hasConcept C71924100 @default.
• W2004207671 hasConcept C86803240 @default.
• W2004207671 hasConceptScore W2004207671C104317684 @default.
• W2004207671 hasConceptScore W2004207671C126322002 @default.
• W2004207671 hasConceptScore W2004207671C134018914 @default.
• W2004207671 hasConceptScore W2004207671C158617107 @default.
• W2004207671 hasConceptScore W2004207671C185592680 @default.
• W2004207671 hasConceptScore W2004207671C199096232 @default.
• W2004207671 hasConceptScore W2004207671C2776330855 @default.
• W2004207671 hasConceptScore W2004207671C2778918659 @default.
• W2004207671 hasConceptScore W2004207671C2779280383 @default.
• W2004207671 hasConceptScore W2004207671C2779959927 @default.
• W2004207671 hasConceptScore W2004207671C2781170229 @default.
• W2004207671 hasConceptScore W2004207671C33288867 @default.
• W2004207671 hasConceptScore W2004207671C41625074 @default.
• W2004207671 hasConceptScore W2004207671C55493867 @default.
• W2004207671 hasConceptScore W2004207671C555293320 @default.
• W2004207671 hasConceptScore W2004207671C71924100 @default.
• W2004207671 hasConceptScore W2004207671C86803240 @default.
• W2004207671 hasIssue "3" @default.
• W2004207671 hasLocation W20042076711 @default.
• W2004207671 hasLocation W20042076712 @default.
• W2004207671 hasLocation W20042076713 @default.
• W2004207671 hasLocation W20042076714 @default.
• W2004207671 hasOpenAccess W2004207671 @default.
• W2004207671 hasPrimaryLocation W20042076711 @default.
• W2004207671 hasRelatedWork W1965127375 @default.
• W2004207671 hasRelatedWork W2005445152 @default.

• next