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• W2004209920 abstract "You have accessJournal of UrologyUrodynamics/Incontinence/Female Urology: Non-Neurogenic Voiding Dysfunction1 Apr 2015MP89-07 A NOMOGRAM FOR EVALUATION OF DETRUSOR CONTRACTILITY IN WOMEN Francoise Valentini and Pierre Nelson Francoise ValentiniFrancoise Valentini More articles by this author and Pierre NelsonPierre Nelson More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2015.02.1806AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Methods developed for men greatly overestimate the detrusor contractility (DC) in women. A reliable parameter PIP1 (= pdet.Qmax + Qmax) has been proposed for older women (1) but to our knowledge, there is no nomogram or parameter allowing to evaluate DC in women over the life span. Our objectives were to carry out a nomogram able to evaluate the detrusor contractility in women from the maximum flow rate Qmax and detrusor pressure at maximum flow pdet.Qmax. METHODS The VBN mathematical knowledge model of micturition (2) introduces 2 mechanical parameters: the detrusor contractility (k) and the urethral obstruction (γ). Some thousand computations using this model allowed to obtain, for a filling bladder volume (Vini)=300 mL, a set of iso-contractility curves in the plane [pdet.Qmax- Qmax] (a nomogram). Due to the Hill's law, this nomogram depended on Vini. So an auxiliary “volume-correction nomogram” was needed to generalize the contractility nomogram to any Vini. Computations were made for a 7F catheter. RESULTS The nomogram for Vini = 300 mL is displayed in Fig L. In Fig R some Qmax vs. Vini curves for sets of k and γ values. Algebraic fitting of these 2 nomograms was then performed. From curves of Fig L one had: k =.965∗(A/B) -.0405 where A and B were polynomials (to simplify Qmax and pdet.Qmax are named Q and P): A = (1+.25∗Q)∗(c+a∗Q +P∗(d+b∗Q)) – 4∗(d+b∗Q) and B = 1 +.25∗Q + 12∗(d+b∗Q) with: a = -.00325; b =.000709; c = -.0948; d =.0172 From Fig R, Qmax was found proportional to (Vini)0.25. Then, the k value was obtained by replacing Q by Q = Q∗(300/Vini)0.25 and P by P = P -.5∗(Q – Q) (3). Algebraic fitting of abacus was easily programmed (Excel or any handheld). CONCLUSIONS This study proposed for the first time a nomogram for detrusor contractility in women which could be used over the life span. The curves' fitting is easily programmable (Excel or handheld) allowing a rapid assessment of detrusor contractility from a pressure-flow study when an impaired detrusor function is suspected in women. 1-NAU 2004; 23:184-9 2-NAU 2000;19:153-76 3-NAU 2014;33:248 © 2015 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 193Issue 4SApril 2015Page: e1102 Advertisement Copyright & Permissions© 2015 by American Urological Association Education and Research, Inc.MetricsAuthor Information Francoise Valentini More articles by this author Pierre Nelson More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ..." @default.
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• W2004209920 title "MP89-07 A NOMOGRAM FOR EVALUATION OF DETRUSOR CONTRACTILITY IN WOMEN" @default.
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