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• W2004213036 abstract "C. elegans cdf-1 was identified in a genetic screen for regulators of Ras-mediated signaling. CDF-1 is a cation diffusion facilitator protein that is structurally and functionally similar to vertebrate ZnT-1. These proteins have an evolutionarily conserved function as positive regulators of the Ras pathway, and the Ras pathway has an evolutionarily conserved ability to respond to CDF proteins. CDF proteins regulate Ras-mediated signaling by promoting Zn(2+) efflux and reducing the concentration of cytosolic Zn(2+), and cytosolic Zn(2+) negatively regulates Ras-mediated signaling. Physiological concentrations of Zn(2+) cause a significant inhibition of Ras-mediated signaling. These findings suggest that Zn(2+) negatively regulates a conserved element of the signaling pathway and that Zn(2+) regulation is important for maintaining the inactive state of the Ras pathway." @default.
• W2004213036 created "2016-06-24" @default.
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• W2004213036 date "2002-05-01" @default.
• W2004213036 modified "2023-09-27" @default.
• W2004213036 title "Zinc Ions and Cation Diffusion Facilitator Proteins Regulate Ras-Mediated Signaling" @default.
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• W2004213036 doi "https://doi.org/10.1016/s1534-5807(02)00151-x" @default.
• W2004213036 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12015965" @default.
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