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• W2004218622 abstract "Production of type I interferon (IFN-α/β) is a common cellular response to virus infection. IFN-α/β has a dual role in combating infection, triggering innate antiviral mechanisms and stimulating the generation of an adaptive immune response. This review focuses on the effects of IFN-α/β on one particular immune cell type, the T cell, and the impact of IFN-α/β-mediated signalling in T cells on the immune response. The critical role of T-cell responsiveness to IFN-α/β for the generation of productive T-cell responses after infections with certain viruses in vivo is discussed in the context of in vitro experiments investigating the mechanisms by which IFN-α/β modifies T-cell function. These studies reveal complex effects of IFN-α/β on T cells, with the consequences of exposure to IFN-α/β depending on the context of other signals received by the T cell." @default.
• W2004218622 created "2016-06-24" @default.
• W2004218622 creator A5029672643 @default.
• W2004218622 date "2012-03-06" @default.
• W2004218622 modified "2023-10-16" @default.
• W2004218622 title "Modulation of T‐cell function by type I interferon" @default.
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• W2004218622 doi "https://doi.org/10.1038/icb.2012.7" @default.
• W2004218622 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22391814" @default.
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