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- W2004221286 abstract "In neuroblastoma × glioma hybrid NG108-15 cells, P 2 purinoceptor agonists inhibited forskolin-stimulated cyclic AMP accumulation with distinct selectivities and their activities could be partially reversed by P 2 purinoceptor antagonists. The rank order of potency in inhibition of cyclic AMP accumulation was UTP > 2-methylthio-ATP (MeSATP) > benzoylbenzoic ATP (BzATP) = α,β-methylene ATP (AMPCPP) > β,γ-methylene ATP (AMPPCP) > ATP > ADP > adenosine 5′-thiotriphosphate (ATPγS). Neither adenosine nor AMP caused any inhibitory effect on cyclic AMP accumulation. Pertussis toxin treatment of cells attenuated the inhibitory effect of UTP, MeSATP and ATP on cyclic AMP accumulation whereas it had no effect on the BzATP-induced response. In addition, P 2 -purinoceptor-mediated inhibition of cyclic AMP accumulation was insensitive to cytosolic Ca 2+ concentration. The breakdown of cyclic AMP was enhanced by MeSATP but not by the addition of ATP, UTP and BzATP. Our results suggest that a pertussis toxin-sensitive G i signalling pathway is directly coupled to the occupancy of P 2 and P 2y receptors in NG108-15 cells." @default.
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- W2004221286 title "P2 purinoceptor-mediated inhibition of cyclic AMP accumulation in NG108-15 cells" @default.
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- W2004221286 doi "https://doi.org/10.1016/0006-8993(96)00645-2" @default.
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