FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2004221438> ?p ?o ?g. }

• W2004221438 endingPage "263" @default.
• W2004221438 startingPage "262" @default.
• W2004221438 abstract "Early-life stress (ELS) is associated with later onset of depression. Early cannabis use may be a risk factor that interacts with environmental factors to increase the risk of psychopathologies. We aimed to examine the long-term effects of ELS on depression- and anxiety-like behavior, and examine whether chronic fatty acid amide hydrolase (FAAH) inhibition during mid-adolescence could ameliorate or exacerbate ELS effects on behavior. Male and female rats were exposed to ELS during post-natal days (P) 7–14, injected with the FAAH inhibitor URB597 (0.4 mg/kg, i.p.) or vehicle for 2 weeks during mid-adolescence (P30–45) or late-adolescence (P45–60). Rats were tested in adulthood for behavior and alterations in CB1 receptors (CB1r) and glucocorticoid receptors (GRs) in the brains’ stress circuit. ELS produced decreased social preference, impaired social recognition, increased learned helplessness and anxiety-like behavior. Administering URB597 during mid-adolescence did not prevent the deleterious long-term effects of ELS on behavior in males and females. When URB597 was administered during late-adolescence, it ameliorated ELS-induced depression- and anxiety-like behavior. Moreover, in males, ELS and URB597 decreased CB1r levels in the prefrontal cortex (PFC) and CA1 and GRs in the PFC and basolateral amygdala (BLA). In females, ELS and URB decreased CB1r in the BLA and GRs in the CA1 and BLA. The findings suggest that mid-adolescence, as opposed to late-adolescence, may not be a potential developmental period for chronic treatment with FAAH inhibitors and that sex-dependent alterations in CB1r and GRs expression in the BLA–PFC–CA1 circuit may contribute to the depressive behavioral phenotype." @default.
• W2004221438 created "2016-06-24" @default.
• W2004221438 creator A5024796415 @default.
• W2004221438 creator A5041886945 @default.
• W2004221438 creator A5051493274 @default.
• W2004221438 creator A5064883303 @default.
• W2004221438 creator A5080980894 @default.
• W2004221438 date "2011-09-01" @default.
• W2004221438 modified "2023-10-14" @default.
• W2004221438 title "Non-replication of interaction between cannabis use and trauma in predicting psychosis" @default.
• W2004221438 cites W2011927445 @default.
• W2004221438 cites W2026301590 @default.
• W2004221438 cites W2032005802 @default.
• W2004221438 cites W2081228663 @default.
• W2004221438 cites W2095877497 @default.
• W2004221438 cites W2114334028 @default.
• W2004221438 cites W2119780182 @default.
• W2004221438 cites W2134882014 @default.
• W2004221438 cites W2147750989 @default.
• W2004221438 cites W2161482219 @default.
• W2004221438 cites W3024608550 @default.
• W2004221438 doi "https://doi.org/10.1016/j.schres.2011.06.012" @default.
• W2004221438 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21745727" @default.
• W2004221438 hasPublicationYear "2011" @default.
• W2004221438 type Work @default.
• W2004221438 sameAs 2004221438 @default.
• W2004221438 citedByCount "20" @default.
• W2004221438 countsByYear W20042214382012 @default.
• W2004221438 countsByYear W20042214382013 @default.
• W2004221438 countsByYear W20042214382014 @default.
• W2004221438 countsByYear W20042214382015 @default.
• W2004221438 countsByYear W20042214382017 @default.
• W2004221438 countsByYear W20042214382018 @default.
• W2004221438 countsByYear W20042214382021 @default.
• W2004221438 crossrefType "journal-article" @default.
• W2004221438 hasAuthorship W2004221438A5024796415 @default.
• W2004221438 hasAuthorship W2004221438A5041886945 @default.
• W2004221438 hasAuthorship W2004221438A5051493274 @default.
• W2004221438 hasAuthorship W2004221438A5064883303 @default.
• W2004221438 hasAuthorship W2004221438A5080980894 @default.
• W2004221438 hasBestOaLocation W20042214382 @default.
• W2004221438 hasConcept C118552586 @default.
• W2004221438 hasConcept C126322002 @default.
• W2004221438 hasConcept C134018914 @default.
• W2004221438 hasConcept C139719470 @default.
• W2004221438 hasConcept C148001335 @default.
• W2004221438 hasConcept C15744967 @default.
• W2004221438 hasConcept C162324750 @default.
• W2004221438 hasConcept C169760540 @default.
• W2004221438 hasConcept C169900460 @default.
• W2004221438 hasConcept C170493617 @default.
• W2004221438 hasConcept C2776867660 @default.
• W2004221438 hasConcept C2778938600 @default.
• W2004221438 hasConcept C2779144063 @default.
• W2004221438 hasConcept C2779727114 @default.
• W2004221438 hasConcept C2779783865 @default.
• W2004221438 hasConcept C2780451725 @default.
• W2004221438 hasConcept C2781144285 @default.
• W2004221438 hasConcept C2781195155 @default.
• W2004221438 hasConcept C42407357 @default.
• W2004221438 hasConcept C558461103 @default.
• W2004221438 hasConcept C71924100 @default.
• W2004221438 hasConceptScore W2004221438C118552586 @default.
• W2004221438 hasConceptScore W2004221438C126322002 @default.
• W2004221438 hasConceptScore W2004221438C134018914 @default.
• W2004221438 hasConceptScore W2004221438C139719470 @default.
• W2004221438 hasConceptScore W2004221438C148001335 @default.
• W2004221438 hasConceptScore W2004221438C15744967 @default.
• W2004221438 hasConceptScore W2004221438C162324750 @default.
• W2004221438 hasConceptScore W2004221438C169760540 @default.
• W2004221438 hasConceptScore W2004221438C169900460 @default.
• W2004221438 hasConceptScore W2004221438C170493617 @default.
• W2004221438 hasConceptScore W2004221438C2776867660 @default.
• W2004221438 hasConceptScore W2004221438C2778938600 @default.
• W2004221438 hasConceptScore W2004221438C2779144063 @default.
• W2004221438 hasConceptScore W2004221438C2779727114 @default.
• W2004221438 hasConceptScore W2004221438C2779783865 @default.
• W2004221438 hasConceptScore W2004221438C2780451725 @default.
• W2004221438 hasConceptScore W2004221438C2781144285 @default.
• W2004221438 hasConceptScore W2004221438C2781195155 @default.
• W2004221438 hasConceptScore W2004221438C42407357 @default.
• W2004221438 hasConceptScore W2004221438C558461103 @default.
• W2004221438 hasConceptScore W2004221438C71924100 @default.
• W2004221438 hasIssue "1-3" @default.
• W2004221438 hasLocation W20042214381 @default.
• W2004221438 hasLocation W20042214382 @default.
• W2004221438 hasLocation W20042214383 @default.
• W2004221438 hasOpenAccess W2004221438 @default.
• W2004221438 hasPrimaryLocation W20042214381 @default.
• W2004221438 hasRelatedWork W1485038464 @default.
• W2004221438 hasRelatedWork W2009796980 @default.
• W2004221438 hasRelatedWork W2021317290 @default.
• W2004221438 hasRelatedWork W2028623309 @default.
• W2004221438 hasRelatedWork W2132765138 @default.
• W2004221438 hasRelatedWork W2184087358 @default.
• W2004221438 hasRelatedWork W2620017265 @default.
• W2004221438 hasRelatedWork W2765649731 @default.
• W2004221438 hasRelatedWork W2902867601 @default.

• next