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- W2004222005 abstract "Platelets pretinned with a neutral Sn(II)-2-mercaptopyridme- N -oxide (SN-MPO) were labeled with 99m Tc and compared to those labeled with 99m Tc-HMPAO. The conditions of labeling platelets, e.g. concentrations of platelets and Sn(II)-MPO, 99m Tc in ACD-saline or ACD-plasma media, pH and incubation time, were optimized using canine platelets. Moderate labeling efficiency was obtained with 20 μg of tin(II) chloride and 30 min incubation with Sn-MPO and pertechnetate. The viability of labeled platelets was determined by platelet recovery and platelet survival times in Beagle dogs. The labeling efficiency with platelets from 43 mL of blood was 62.8 ± 7.6%. The platelet recovery was 35.7 ± 5.0% and exponential survival time was 34.6 ± 3.1 h compared to 43.3 ± 12.0% and 29.5 ± 3.3 h for 99m Tc-HMPAO-labeled platelets. These values were significantly ( P < 0.01) lower than 111 In-labeled platelets. Biodistribution in dogs indicates lower retention in blood, spleen and liver after some initial 99m Tc excretion in urine. The platelet deposition with 99m Tc platelets (Sn-MPO method) on polyurethane angio-catheters was similar to 99m Tc-HMPAO-labeled platelets. This study indicates that the platelets could be successfully labeled with pertechnetate in a cost-effective manner for the evaluation of thromboembolic complications." @default.
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- W2004222005 date "1991-01-01" @default.
- W2004222005 modified "2023-09-26" @default.
- W2004222005 title "Technetium-99m-labeled platelets: Comparison of labeling with a new lipid-soluble Sn(II)-mercaptopyridine-N-oxide and 99mTc-HMPAO" @default.
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- W2004222005 doi "https://doi.org/10.1016/0883-2897(91)90106-u" @default.
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