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- W2004223664 abstract "We studied the possible role of serotonergic systems in the cause of premenstrual affective symptoms.The binding of tritium-labeled imipramine to platelets is thought to parallel central nervous system binding and to indicate serotonergic activity. We measured platelet tritium-labeled imipramine binding sites in the follicular and luteal phases in 12 controls and in 9 women with well-documented late luteal phase dysphoric disorder. In statistical analyses we used repeated measures analysis of variance, with Student-Newman-Keuls and Duncan's one-tailed t tests, and Pearson's r.The values of subjects with late luteal phase dysphoric disorder were lower than those of controls (F [1,39] = 5.13, p = 0.03). Both follicular and luteal phase level were lower in subjects with late luteal phase dysphoric disorder but reached statistical significance only in the follicular phase.Lower platelet tritium-labeled imipramine binding in women with late luteal phase dysphoric disorder supports the hypothesis that alteration of central serotonergic systems may contribute to premenstrual dysphoric symptoms." @default.
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- W2004223664 date "1992-07-01" @default.
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- W2004223664 title "Reduced platelet tritium-labeled imipramine binding sites in women with premenstrual syndrome" @default.
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- W2004223664 doi "https://doi.org/10.1016/s0002-9378(11)91653-6" @default.
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