FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2004227612> ?p ?o ?g. }

• W2004227612 endingPage "300" @default.
• W2004227612 startingPage "295" @default.
• W2004227612 abstract "A long-term clinical trial of 1-15 months has been carried out with the oral iron chelator 1,2-dimethyl-3-hydroxypyrid-4-one (L1) in 13 transfusion-dependent iron-loaded patients. Urinary iron excretion was greatest in patients with thalassaemia major and was related to the number of previous transfusions but not to the serum ferritin level. Substantial increases of urinary iron were observed in all the patients when the frequency of the daily dose was doubled and in response to 2 x 3 g L1 daily 11 of 12 patients tested excreted greater than 25 mg iron daily, the mean daily intake of iron from transfusion. Serum ferritin levels have fluctuated but overall have remained unchanged. Pharmacological studies in five patients have indicated rapid absorption probably from the stomach and variable plasma half life of 77 +/- 35 min (X +/- SD). Glucuronation was identified as a major route of L1 metabolism. Short-term intensive chelation studies using repeated administration of L1 resulted in further increases of urinary iron excretion by comparison to a single dose. In one case 325 mg of iron were excreted in the urine following the administration of 16 g (5 x 2 g + 2 x 3 g) within 24 h. Iron excretion studies were carried out in six transfusional iron-loaded patients who were maintained on a low iron diet before and during chelation. No significant increases of faecal iron excretion were observed with L1 using daily doses of up to 3 x 3 g and 4 x 2 g. The high level of compliance during treatment with L1 and the levels of urine iron excretion that can be achieved increase the prospects for oral chelation in transfusional iron-loaded patients." @default.
• W2004227612 created "2016-06-24" @default.
• W2004227612 creator A5003949490 @default.
• W2004227612 creator A5020503984 @default.
• W2004227612 creator A5027392849 @default.
• W2004227612 creator A5049344873 @default.
• W2004227612 creator A5061926072 @default.
• W2004227612 creator A5067503432 @default.
• W2004227612 creator A5069333681 @default.
• W2004227612 date "1990-10-01" @default.
• W2004227612 modified "2023-10-04" @default.
• W2004227612 title "Long-term trial with the oral iron chelator 1,2-dimethyl-3-hydroxypyrid-4-one (L₁) I. IRON CHELATION AND METABOLIC STUDIES" @default.
• W2004227612 cites W1533060086 @default.
• W2004227612 cites W1972825203 @default.
• W2004227612 cites W1981654769 @default.
• W2004227612 cites W1991603069 @default.
• W2004227612 cites W2003862510 @default.
• W2004227612 cites W2020134645 @default.
• W2004227612 cites W2027016374 @default.
• W2004227612 cites W2045834061 @default.
• W2004227612 cites W2049385753 @default.
• W2004227612 cites W2053355927 @default.
• W2004227612 cites W2066853173 @default.
• W2004227612 cites W2081568231 @default.
• W2004227612 cites W2090136536 @default.
• W2004227612 cites W2160645804 @default.
• W2004227612 cites W4233481014 @default.
• W2004227612 doi "https://doi.org/10.1111/j.1365-2141.1990.tb07887.x" @default.
• W2004227612 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2094333" @default.
• W2004227612 hasPublicationYear "1990" @default.
• W2004227612 type Work @default.
• W2004227612 sameAs 2004227612 @default.
• W2004227612 citedByCount "127" @default.
• W2004227612 countsByYear W20042276122012 @default.
• W2004227612 countsByYear W20042276122013 @default.
• W2004227612 countsByYear W20042276122014 @default.
• W2004227612 countsByYear W20042276122015 @default.
• W2004227612 countsByYear W20042276122016 @default.
• W2004227612 countsByYear W20042276122018 @default.
• W2004227612 countsByYear W20042276122019 @default.
• W2004227612 countsByYear W20042276122020 @default.
• W2004227612 countsByYear W20042276122022 @default.
• W2004227612 countsByYear W20042276122023 @default.
• W2004227612 crossrefType "journal-article" @default.
• W2004227612 hasAuthorship W2004227612A5003949490 @default.
• W2004227612 hasAuthorship W2004227612A5020503984 @default.
• W2004227612 hasAuthorship W2004227612A5027392849 @default.
• W2004227612 hasAuthorship W2004227612A5049344873 @default.
• W2004227612 hasAuthorship W2004227612A5061926072 @default.
• W2004227612 hasAuthorship W2004227612A5067503432 @default.
• W2004227612 hasAuthorship W2004227612A5069333681 @default.
• W2004227612 hasConcept C10146269 @default.
• W2004227612 hasConcept C126322002 @default.
• W2004227612 hasConcept C179104552 @default.
• W2004227612 hasConcept C185592680 @default.
• W2004227612 hasConcept C197404232 @default.
• W2004227612 hasConcept C2777056448 @default.
• W2004227612 hasConcept C2777218474 @default.
• W2004227612 hasConcept C2777799968 @default.
• W2004227612 hasConcept C2778319317 @default.
• W2004227612 hasConcept C2778917026 @default.
• W2004227612 hasConcept C2779875672 @default.
• W2004227612 hasConcept C2780026642 @default.
• W2004227612 hasConcept C2781053155 @default.
• W2004227612 hasConcept C71924100 @default.
• W2004227612 hasConcept C77411442 @default.
• W2004227612 hasConcept C90924648 @default.
• W2004227612 hasConceptScore W2004227612C10146269 @default.
• W2004227612 hasConceptScore W2004227612C126322002 @default.
• W2004227612 hasConceptScore W2004227612C179104552 @default.
• W2004227612 hasConceptScore W2004227612C185592680 @default.
• W2004227612 hasConceptScore W2004227612C197404232 @default.
• W2004227612 hasConceptScore W2004227612C2777056448 @default.
• W2004227612 hasConceptScore W2004227612C2777218474 @default.
• W2004227612 hasConceptScore W2004227612C2777799968 @default.
• W2004227612 hasConceptScore W2004227612C2778319317 @default.
• W2004227612 hasConceptScore W2004227612C2778917026 @default.
• W2004227612 hasConceptScore W2004227612C2779875672 @default.
• W2004227612 hasConceptScore W2004227612C2780026642 @default.
• W2004227612 hasConceptScore W2004227612C2781053155 @default.
• W2004227612 hasConceptScore W2004227612C71924100 @default.
• W2004227612 hasConceptScore W2004227612C77411442 @default.
• W2004227612 hasConceptScore W2004227612C90924648 @default.
• W2004227612 hasIssue "2" @default.
• W2004227612 hasLocation W20042276121 @default.
• W2004227612 hasLocation W20042276122 @default.
• W2004227612 hasOpenAccess W2004227612 @default.
• W2004227612 hasPrimaryLocation W20042276121 @default.
• W2004227612 hasRelatedWork W1980414588 @default.
• W2004227612 hasRelatedWork W2040777684 @default.
• W2004227612 hasRelatedWork W2050995642 @default.
• W2004227612 hasRelatedWork W2064828098 @default.
• W2004227612 hasRelatedWork W2078335998 @default.
• W2004227612 hasRelatedWork W2094173166 @default.
• W2004227612 hasRelatedWork W2107904872 @default.
• W2004227612 hasRelatedWork W2206137041 @default.
• W2004227612 hasRelatedWork W3049642791 @default.
• W2004227612 hasRelatedWork W4246286387 @default.

• next