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- W2004227617 abstract "Aberrant Wnt/β-catenin signaling following loss of the tumor suppressor adenomatous polyposis coli (APC) is thought to initiate colon adenoma formation. Considerable evidence for this model has come from mouse models of Apc truncation where nuclear β-catenin is detectable soon after loss of Apc. However, examination of tumors from familial adenomatous polyposis coli (FAP) patients has failed to confirm the presence of nuclear β-catenin in early lesions following APC loss despite robust staining in later lesions. This observation presents the possibility that colon adenomas arise through a β-catenin-independent function of APC. Additionally, there is a well established role for inflammation and specifically COX-2 and prostaglandin E2 in the progression of colorectal cancer. Here we review the current literature regarding the functions of APC in regulating WNT/β-catenin signaling as well as its control of intestinal cell fate and differentiation. Further, we provide a brief commentary on our current understanding of the role that inflammation plays in colorectal tumorigenesis and how it fits in with APC dysfunction. Though there are currently contrasting models to explain colon tumorigenesis, our goal is to begin to reconcile data from multiple different model systems and provide a functional view into the initiation and progression of colon cancer." @default.
- W2004227617 created "2016-06-24" @default.
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- W2004227617 creator A5045918107 @default.
- W2004227617 creator A5052754584 @default.
- W2004227617 creator A5061837046 @default.
- W2004227617 date "2009-08-15" @default.
- W2004227617 modified "2023-09-29" @default.
- W2004227617 title "New perspectives on APC control of cell fate and proliferation in colorectal cancer" @default.
- W2004227617 cites W1482218984 @default.
- W2004227617 cites W1570736525 @default.
- W2004227617 cites W1582072542 @default.
- W2004227617 cites W1648593433 @default.
- W2004227617 cites W1666932156 @default.
- W2004227617 cites W1783022590 @default.
- W2004227617 cites W1868796410 @default.
- W2004227617 cites W1907972050 @default.
- W2004227617 cites W1967137553 @default.
- W2004227617 cites W1969959095 @default.
- W2004227617 cites W1975560535 @default.
- W2004227617 cites W1975912195 @default.
- W2004227617 cites W1981498981 @default.
- W2004227617 cites W1984353621 @default.
- W2004227617 cites W1986197876 @default.
- W2004227617 cites W1988136514 @default.
- W2004227617 cites W1991756459 @default.
- W2004227617 cites W1992372073 @default.
- W2004227617 cites W1995660054 @default.
- W2004227617 cites W2001992345 @default.
- W2004227617 cites W2006239354 @default.
- W2004227617 cites W2007278554 @default.
- W2004227617 cites W2017557668 @default.
- W2004227617 cites W2018425992 @default.
- W2004227617 cites W2025187621 @default.
- W2004227617 cites W2030350068 @default.
- W2004227617 cites W2038078260 @default.
- W2004227617 cites W2044210875 @default.
- W2004227617 cites W2046345325 @default.
- W2004227617 cites W2050642264 @default.
- W2004227617 cites W2051686420 @default.
- W2004227617 cites W2051751077 @default.
- W2004227617 cites W2053029064 @default.
- W2004227617 cites W2055951936 @default.
- W2004227617 cites W2057156659 @default.
- W2004227617 cites W2057252291 @default.
- W2004227617 cites W2057830803 @default.
- W2004227617 cites W2058194940 @default.
- W2004227617 cites W2059659604 @default.
- W2004227617 cites W2080480789 @default.
- W2004227617 cites W2080842591 @default.
- W2004227617 cites W2084002971 @default.
- W2004227617 cites W2086222354 @default.
- W2004227617 cites W2086747104 @default.
- W2004227617 cites W2095169768 @default.
- W2004227617 cites W2096724850 @default.
- W2004227617 cites W2097620342 @default.
- W2004227617 cites W2104764813 @default.
- W2004227617 cites W2115014494 @default.
- W2004227617 cites W2115833116 @default.
- W2004227617 cites W2116861117 @default.
- W2004227617 cites W2120155792 @default.
- W2004227617 cites W2122355853 @default.
- W2004227617 cites W2122935465 @default.
- W2004227617 cites W2126853519 @default.
- W2004227617 cites W2134359750 @default.
- W2004227617 cites W2135715423 @default.
- W2004227617 cites W2135938816 @default.
- W2004227617 cites W2139385582 @default.
- W2004227617 cites W2142888319 @default.
- W2004227617 cites W2143036744 @default.
- W2004227617 cites W2148558073 @default.
- W2004227617 cites W2148883613 @default.
- W2004227617 cites W2148907720 @default.
- W2004227617 cites W2148968748 @default.
- W2004227617 cites W2149386947 @default.
- W2004227617 cites W2149876509 @default.
- W2004227617 cites W2151365378 @default.
- W2004227617 cites W2152678597 @default.
- W2004227617 cites W2157452165 @default.
- W2004227617 cites W2163008314 @default.
- W2004227617 cites W2169580709 @default.
- W2004227617 cites W2170183018 @default.
- W2004227617 cites W2171974881 @default.
- W2004227617 cites W2275032079 @default.
- W2004227617 cites W2278715806 @default.
- W2004227617 cites W2329360646 @default.
- W2004227617 cites W2330709704 @default.
- W2004227617 cites W2336215030 @default.
- W2004227617 doi "https://doi.org/10.4161/cc.8.16.9278" @default.
- W2004227617 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19597346" @default.
- W2004227617 hasPublicationYear "2009" @default.
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