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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2004227773> ?p ?o ?g. }

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• W2004227773 abstract "While recent evidence from several laboratories has shown that interleukin-4 (IL-4) can act on a number of cells in addition to B lymphocytes, these have thus far been limited to cells of the hematopoietic lineage. Here we report that murine IL-4 promotes DNA synthesis in both primary and immortalized fibroblasts. Marked stimulation of [3H]thymidine incorporation was observed for primary skin fibroblasts of Balb/c3T3 cells stimulated with HPLC- or immunoaffinity-purified as well as recombinant IL-4. Responses to immunoaffinity and recombinant IL-4 were completely blocked with anti-IL-4 antibody. Similar dose/response relationships were observed for recombinant IL-4 on skin fibroblasts and an IL-4 responsive murine T cell tumor, suggesting that the receptors for this lymphokine on these cells is simular. Together, these results show that IL-4 can cause DNA synthesis by murine fibroblasts presumably through ligand-receptor interactions at the cell surface. Implications of these findings to inflammation during an immune response is discussed." @default.
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• W2004227773 date "1988-11-01" @default.
• W2004227773 modified "2023-10-18" @default.
• W2004227773 title "Lymphokine regulation of inflammatory processes: Interleukin-4 stimulates fibroblast proliferation" @default.
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• W2004227773 doi "https://doi.org/10.1016/0090-1229(88)90119-5" @default.
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