Matches in SemOpenAlex for { <https://semopenalex.org/work/W2004228498> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W2004228498 endingPage "526" @default.
- W2004228498 startingPage "519" @default.
- W2004228498 abstract "ObjectiveNonsteroidal anti-inflammatory drugs (NSAIDs) are widely used in the treatment of osteoarthritis (OA). For the outcome of treatment the direct effects of NSAIDs on cartilage may be more important than indirect effects on inflammation, considered being secondary in OA. For clinical practice, it is relevant to study effects of NSAIDs on early stages of OA. Therefore we studied the direct effects of celecoxib on human degenerated OA cartilage and compared the effects with those on human healthy cartilage and human end-stage OA cartilage.MethodsDegenerated, late-stage OA, and healthy human articular cartilage were exposed (7 days of culture) to celecoxib (0.1–10 μM). Changes in cartilage proteoglycan turnover (synthesis, retention, and release), proteoglycan content, prostaglandin E2 (PGE2) and nitric oxide (NO) production were determined.ResultsBoth degenerated and established OA cartilage showed its characteristic changes in proteoglycan turnover (all P<0.05). Celecoxib at 1 μM was able to increase synthesis of degenerated cartilage and normalize both releases of newly formed and resident proteoglycans. Importantly, 1 μM celecoxib influenced matrix integrity by enhancing proteoglycan content. Similar results were found for end-stage OA cartilage. Enhanced PGE2 production in degenerative and OA cartilage could be decreased by celecoxib, whereas no effect on enhanced NO production was found. No significant effects of celecoxib on normal cartilage were found.DiscussionCelecoxib, in a clinical relevant concentration, showed in vitro a significant beneficial effect, not only on late-stage OA but also on more early stages of OA, whereas healthy cartilage remained unaffected, suggesting chondroprotective properties of celecoxib in the treatment of degenerative joint disorders." @default.
- W2004228498 created "2016-06-24" @default.
- W2004228498 creator A5017043157 @default.
- W2004228498 creator A5022871817 @default.
- W2004228498 creator A5063928355 @default.
- W2004228498 date "2005-06-01" @default.
- W2004228498 modified "2023-10-06" @default.
- W2004228498 title "Selective COX-2 inhibition is favorable to human early and late-stage osteoarthritic cartilage: a human in vitro study" @default.
- W2004228498 cites W124630626 @default.
- W2004228498 cites W1586647561 @default.
- W2004228498 cites W1969790876 @default.
- W2004228498 cites W1971255663 @default.
- W2004228498 cites W1984387113 @default.
- W2004228498 cites W1995617534 @default.
- W2004228498 cites W2026109741 @default.
- W2004228498 cites W2041517292 @default.
- W2004228498 cites W2053538354 @default.
- W2004228498 cites W2061473393 @default.
- W2004228498 cites W2063355095 @default.
- W2004228498 cites W2066074947 @default.
- W2004228498 cites W2082785714 @default.
- W2004228498 cites W2093048739 @default.
- W2004228498 cites W2117227343 @default.
- W2004228498 cites W2133192455 @default.
- W2004228498 cites W2149233326 @default.
- W2004228498 cites W2158811477 @default.
- W2004228498 cites W2159386800 @default.
- W2004228498 cites W2170651748 @default.
- W2004228498 cites W2172253009 @default.
- W2004228498 cites W2725056820 @default.
- W2004228498 cites W4241343866 @default.
- W2004228498 cites W4292542165 @default.
- W2004228498 doi "https://doi.org/10.1016/j.joca.2005.02.004" @default.
- W2004228498 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15922186" @default.
- W2004228498 hasPublicationYear "2005" @default.
- W2004228498 type Work @default.
- W2004228498 sameAs 2004228498 @default.
- W2004228498 citedByCount "70" @default.
- W2004228498 countsByYear W20042284982012 @default.
- W2004228498 countsByYear W20042284982013 @default.
- W2004228498 countsByYear W20042284982014 @default.
- W2004228498 countsByYear W20042284982015 @default.
- W2004228498 countsByYear W20042284982017 @default.
- W2004228498 countsByYear W20042284982018 @default.
- W2004228498 countsByYear W20042284982019 @default.
- W2004228498 countsByYear W20042284982020 @default.
- W2004228498 countsByYear W20042284982021 @default.
- W2004228498 countsByYear W20042284982022 @default.
- W2004228498 countsByYear W20042284982023 @default.
- W2004228498 crossrefType "journal-article" @default.
- W2004228498 hasAuthorship W2004228498A5017043157 @default.
- W2004228498 hasAuthorship W2004228498A5022871817 @default.
- W2004228498 hasAuthorship W2004228498A5063928355 @default.
- W2004228498 hasBestOaLocation W20042284981 @default.
- W2004228498 hasConcept C105702510 @default.
- W2004228498 hasConcept C126322002 @default.
- W2004228498 hasConcept C134018914 @default.
- W2004228498 hasConcept C142724271 @default.
- W2004228498 hasConcept C185592680 @default.
- W2004228498 hasConcept C204787440 @default.
- W2004228498 hasConcept C2776164576 @default.
- W2004228498 hasConcept C2776467144 @default.
- W2004228498 hasConcept C2777956040 @default.
- W2004228498 hasConcept C2779335624 @default.
- W2004228498 hasConcept C2780550940 @default.
- W2004228498 hasConcept C71924100 @default.
- W2004228498 hasConceptScore W2004228498C105702510 @default.
- W2004228498 hasConceptScore W2004228498C126322002 @default.
- W2004228498 hasConceptScore W2004228498C134018914 @default.
- W2004228498 hasConceptScore W2004228498C142724271 @default.
- W2004228498 hasConceptScore W2004228498C185592680 @default.
- W2004228498 hasConceptScore W2004228498C204787440 @default.
- W2004228498 hasConceptScore W2004228498C2776164576 @default.
- W2004228498 hasConceptScore W2004228498C2776467144 @default.
- W2004228498 hasConceptScore W2004228498C2777956040 @default.
- W2004228498 hasConceptScore W2004228498C2779335624 @default.
- W2004228498 hasConceptScore W2004228498C2780550940 @default.
- W2004228498 hasConceptScore W2004228498C71924100 @default.
- W2004228498 hasIssue "6" @default.
- W2004228498 hasLocation W20042284981 @default.
- W2004228498 hasLocation W20042284982 @default.
- W2004228498 hasOpenAccess W2004228498 @default.
- W2004228498 hasPrimaryLocation W20042284981 @default.
- W2004228498 hasRelatedWork W1511359292 @default.
- W2004228498 hasRelatedWork W2002974844 @default.
- W2004228498 hasRelatedWork W2013790334 @default.
- W2004228498 hasRelatedWork W2027454293 @default.
- W2004228498 hasRelatedWork W2053538354 @default.
- W2004228498 hasRelatedWork W2168482704 @default.
- W2004228498 hasRelatedWork W2243496470 @default.
- W2004228498 hasRelatedWork W2296161118 @default.
- W2004228498 hasRelatedWork W2351785163 @default.
- W2004228498 hasRelatedWork W2748952813 @default.
- W2004228498 hasVolume "13" @default.
- W2004228498 isParatext "false" @default.
- W2004228498 isRetracted "false" @default.
- W2004228498 magId "2004228498" @default.
- W2004228498 workType "article" @default.