FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2004228515> ?p ?o ?g. }

• W2004228515 endingPage "3049" @default.
• W2004228515 startingPage "3041" @default.
• W2004228515 abstract "Influenza A viruses cause annual epidemics and irregular pandemics. A vaccine with heterosubtypic protection (hetero-protection) has been needed. In the present study, various influenza H1, H3, H5, and H9 hemagglutinin (HA) proteins were expressed in insect cells, and then mice were subcutaneously immunized with the expressed HA proteins, and challenged by influenza A viruses (A/Puerto Rico/8/1934 (H1N1) or A/chicken/Guangdong/96 (H9N2)). The results first showed that wild-type H3 hemagglutinin (HA) (H3-WT), but not a transmembrane domain (TM) mutant, had hetero-protection against both H1N1 and H9N2 with survival rates of 17% and 33% respectively, and that wild-type H1 (H1-WT), H5 (H5-WT) and H9 (H9-WT) had no hetero-protection against H1N1 or H9N2 except for H5-WT against H1N1 with a survival rate of 17%. Then the H3-WT TM replaced the TMs of H1-WT, H5-WT and H9-WT to generate recombinant H1-TM, H5-TM and H9-TM respectively, and whether the H3-WT TM-dependent hetero-protection could be transferred to these TM mutants was investigated. The results showed that the H3-WT TM-dependent hetero-protection was transferable. H1-TM against H9N2 and H9-TM against H1N1 were with survival rates of 33% and 17% respectively, and H5-TM against both H1N1 and H9N2 with survival rates of 50% and 17% respectively. Furthermore, higher dosage H5-TM scored 100% hetero-protection against H1N1. These results demonstrated that replacement of the TMs of non-H3 HAs with H3-WT TM could enhance their hetero-protection. These findings would help the development of future influenza vaccines against pandemics such as the recently appeared H7N9 infection." @default.
• W2004228515 created "2016-06-24" @default.
• W2004228515 creator A5013752180 @default.
• W2004228515 creator A5015873182 @default.
• W2004228515 creator A5016249722 @default.
• W2004228515 creator A5021745084 @default.
• W2004228515 creator A5031371726 @default.
• W2004228515 creator A5045570568 @default.
• W2004228515 creator A5059797825 @default.
• W2004228515 creator A5072289834 @default.
• W2004228515 creator A5075356724 @default.
• W2004228515 creator A5089990345 @default.
• W2004228515 date "2014-05-01" @default.
• W2004228515 modified "2023-09-30" @default.
• W2004228515 title "Recombinant influenza H1, H5 and H9 hemagglutinins containing replaced H3 hemagglutinin transmembrane domain showed enhanced heterosubtypic protection in mice" @default.
• W2004228515 cites W1533249294 @default.
• W2004228515 cites W1546151618 @default.
• W2004228515 cites W1966893415 @default.
• W2004228515 cites W1968895930 @default.
• W2004228515 cites W1972012737 @default.
• W2004228515 cites W1972684176 @default.
• W2004228515 cites W1978449792 @default.
• W2004228515 cites W1990545448 @default.
• W2004228515 cites W1994482345 @default.
• W2004228515 cites W1995683629 @default.
• W2004228515 cites W2002844537 @default.
• W2004228515 cites W2004396083 @default.
• W2004228515 cites W2010820891 @default.
• W2004228515 cites W2037343509 @default.
• W2004228515 cites W2037859752 @default.
• W2004228515 cites W2041836794 @default.
• W2004228515 cites W2047473309 @default.
• W2004228515 cites W2059992667 @default.
• W2004228515 cites W2069831575 @default.
• W2004228515 cites W2071629929 @default.
• W2004228515 cites W2075021882 @default.
• W2004228515 cites W2076909664 @default.
• W2004228515 cites W2080330697 @default.
• W2004228515 cites W2080855765 @default.
• W2004228515 cites W2096565446 @default.
• W2004228515 cites W2099127292 @default.
• W2004228515 cites W2116050586 @default.
• W2004228515 cites W2116073355 @default.
• W2004228515 cites W2123183607 @default.
• W2004228515 cites W2152912310 @default.
• W2004228515 cites W2159734253 @default.
• W2004228515 cites W2162889321 @default.
• W2004228515 cites W2163600246 @default.
• W2004228515 doi "https://doi.org/10.1016/j.vaccine.2014.03.058" @default.
• W2004228515 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7115591" @default.
• W2004228515 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24704333" @default.
• W2004228515 hasPublicationYear "2014" @default.
• W2004228515 type Work @default.
• W2004228515 sameAs 2004228515 @default.
• W2004228515 citedByCount "19" @default.
• W2004228515 countsByYear W20042285152014 @default.
• W2004228515 countsByYear W20042285152015 @default.
• W2004228515 countsByYear W20042285152016 @default.
• W2004228515 countsByYear W20042285152017 @default.
• W2004228515 countsByYear W20042285152018 @default.
• W2004228515 countsByYear W20042285152019 @default.
• W2004228515 countsByYear W20042285152020 @default.
• W2004228515 countsByYear W20042285152022 @default.
• W2004228515 countsByYear W20042285152023 @default.
• W2004228515 crossrefType "journal-article" @default.
• W2004228515 hasAuthorship W2004228515A5013752180 @default.
• W2004228515 hasAuthorship W2004228515A5015873182 @default.
• W2004228515 hasAuthorship W2004228515A5016249722 @default.
• W2004228515 hasAuthorship W2004228515A5021745084 @default.
• W2004228515 hasAuthorship W2004228515A5031371726 @default.
• W2004228515 hasAuthorship W2004228515A5045570568 @default.
• W2004228515 hasAuthorship W2004228515A5059797825 @default.
• W2004228515 hasAuthorship W2004228515A5072289834 @default.
• W2004228515 hasAuthorship W2004228515A5075356724 @default.
• W2004228515 hasAuthorship W2004228515A5089990345 @default.
• W2004228515 hasBestOaLocation W20042285151 @default.
• W2004228515 hasConcept C104317684 @default.
• W2004228515 hasConcept C143065580 @default.
• W2004228515 hasConcept C159047783 @default.
• W2004228515 hasConcept C185592680 @default.
• W2004228515 hasConcept C207583985 @default.
• W2004228515 hasConcept C2522874641 @default.
• W2004228515 hasConcept C2777546802 @default.
• W2004228515 hasConcept C2778692840 @default.
• W2004228515 hasConcept C40767141 @default.
• W2004228515 hasConcept C519248777 @default.
• W2004228515 hasConcept C55493867 @default.
• W2004228515 hasConcept C86803240 @default.
• W2004228515 hasConceptScore W2004228515C104317684 @default.
• W2004228515 hasConceptScore W2004228515C143065580 @default.
• W2004228515 hasConceptScore W2004228515C159047783 @default.
• W2004228515 hasConceptScore W2004228515C185592680 @default.
• W2004228515 hasConceptScore W2004228515C207583985 @default.
• W2004228515 hasConceptScore W2004228515C2522874641 @default.
• W2004228515 hasConceptScore W2004228515C2777546802 @default.
• W2004228515 hasConceptScore W2004228515C2778692840 @default.
• W2004228515 hasConceptScore W2004228515C40767141 @default.
• W2004228515 hasConceptScore W2004228515C519248777 @default.

• next