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- W2004228927 abstract "Type II T4 5'-deiodinase plays an essential role in converting T4 to T3 in extrathyroidal tissues, thus allowing the full development of a cellular effect of thyroid hormone. This enzyme is one of the most important factors in regulating local action of thyroid hormone. Its activity in the rat pineal was 20-30 times higher at midnight than at noon; this nocturnal rise was abolished by the beta-adrenergic blocker, propranolol. The beta-agonist isoproterenol, caused a 3-fold increase in diurnal enzyme activity. There is thus a marked nyctohemeral variation in T4 activation in the pineal, probably mediated by a beta-adrenergic mechanism. Since the temporal peak of pineal T4 activation corresponds to that of pineal function, our data suggest a previously unrecognized role of thyroid hormone in pineal regulation." @default.
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- W2004228927 date "1987-07-01" @default.
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- W2004228927 title "Rhythmicity of Triiodothyronine Generation by Type II Thyroxine 5′-Deiodinase in Rat Pineal Is Mediated by a β-Adrenergic Mechanism*" @default.
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- W2004228927 doi "https://doi.org/10.1210/endo-121-1-74" @default.
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