FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2004229999> ?p ?o ?g. }

• W2004229999 endingPage "56" @default.
• W2004229999 startingPage "49" @default.
• W2004229999 abstract "By generating prostaglandins, cyclooxygenase-2 (Cox-2/Ptgs2) plays a critical role in regulating inflammatory responses. While several inflammatory stimuli have been shown to increase Ptgs2 expression, less is known about how the transcription of this gene is terminated. Here we show that stimulation of macrophages with yeast zymosan, a TLR2/6 and dectin-1 agonist, causes a transient increase in the expression of Ptgs2 accompanied by a simultaneous increase in the expression of the transcriptional repressor, activating transcription factor-3 (Atf3). The expression of Ptgs2 was significantly higher in resident peritoneal macrophages isolated from Atf3(-/-) mice than that from Atf3(+/+) mice and was associated with higher prostaglandin production upon stimulation with zymosan. In activated macrophages, Atf3 accumulated in the nucleus and chromatin-immunoprecipitation analysis showed that Atf3 is recruited to the Ptgs2 promoter region. In acute peritonitis and in cutaneous wounds, there was increased leukocyte accumulation and higher levels of prostaglandins (PGE2/PGD2) in inflammatory exudates of Atf3(-/-) mice compared with WT mice. Collectively, these results demonstrate that during acute inflammation Atf3 negatively regulates Ptgs2 and therefore dysregulation of this axis could potentially contribute to aberrant Ptgs2 expression in chronic inflammatory diseases. Moreover, this axis could be a new therapeutic target for suppressing Ptgs2 expression and the resultant inflammatory responses." @default.
• W2004229999 created "2016-06-24" @default.
• W2004229999 creator A5012248310 @default.
• W2004229999 creator A5022942037 @default.
• W2004229999 creator A5053263135 @default.
• W2004229999 creator A5066730609 @default.
• W2004229999 creator A5072415149 @default.
• W2004229999 creator A5073817755 @default.
• W2004229999 creator A5078555736 @default.
• W2004229999 date "2015-01-01" @default.
• W2004229999 modified "2023-10-01" @default.
• W2004229999 title "Atf3 negatively regulates Ptgs2/Cox2 expression during acute inflammation" @default.
• W2004229999 cites W1497700962 @default.
• W2004229999 cites W1539392991 @default.
• W2004229999 cites W1541709451 @default.
• W2004229999 cites W1578893636 @default.
• W2004229999 cites W1687972305 @default.
• W2004229999 cites W1952047265 @default.
• W2004229999 cites W1967070632 @default.
• W2004229999 cites W1981382753 @default.
• W2004229999 cites W1983754832 @default.
• W2004229999 cites W1990014836 @default.
• W2004229999 cites W1993223905 @default.
• W2004229999 cites W1995197795 @default.
• W2004229999 cites W2001162433 @default.
• W2004229999 cites W2013777179 @default.
• W2004229999 cites W2013926748 @default.
• W2004229999 cites W2028906750 @default.
• W2004229999 cites W2030571587 @default.
• W2004229999 cites W2036584139 @default.
• W2004229999 cites W2060527543 @default.
• W2004229999 cites W2063136699 @default.
• W2004229999 cites W2063292874 @default.
• W2004229999 cites W2064573089 @default.
• W2004229999 cites W2073652336 @default.
• W2004229999 cites W2075650444 @default.
• W2004229999 cites W2089767083 @default.
• W2004229999 cites W2093785176 @default.
• W2004229999 cites W2097404490 @default.
• W2004229999 cites W2098296304 @default.
• W2004229999 cites W2103921344 @default.
• W2004229999 cites W2107531246 @default.
• W2004229999 cites W2109577877 @default.
• W2004229999 cites W2112189542 @default.
• W2004229999 cites W2116459455 @default.
• W2004229999 cites W2126746388 @default.
• W2004229999 cites W2127604161 @default.
• W2004229999 cites W2129935236 @default.
• W2004229999 cites W2139389545 @default.
• W2004229999 cites W2145221987 @default.
• W2004229999 cites W2160007416 @default.
• W2004229999 cites W2162392154 @default.
• W2004229999 cites W2162392926 @default.
• W2004229999 cites W2166102027 @default.
• W2004229999 cites W2166218639 @default.
• W2004229999 cites W4214593906 @default.
• W2004229999 cites W4367138785 @default.
• W2004229999 doi "https://doi.org/10.1016/j.prostaglandins.2015.01.001" @default.
• W2004229999 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4386069" @default.
• W2004229999 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25619459" @default.
• W2004229999 hasPublicationYear "2015" @default.
• W2004229999 type Work @default.
• W2004229999 sameAs 2004229999 @default.
• W2004229999 citedByCount "39" @default.
• W2004229999 countsByYear W20042299992016 @default.
• W2004229999 countsByYear W20042299992017 @default.
• W2004229999 countsByYear W20042299992018 @default.
• W2004229999 countsByYear W20042299992019 @default.
• W2004229999 countsByYear W20042299992020 @default.
• W2004229999 countsByYear W20042299992021 @default.
• W2004229999 countsByYear W20042299992022 @default.
• W2004229999 countsByYear W20042299992023 @default.
• W2004229999 crossrefType "journal-article" @default.
• W2004229999 hasAuthorship W2004229999A5012248310 @default.
• W2004229999 hasAuthorship W2004229999A5022942037 @default.
• W2004229999 hasAuthorship W2004229999A5053263135 @default.
• W2004229999 hasAuthorship W2004229999A5066730609 @default.
• W2004229999 hasAuthorship W2004229999A5072415149 @default.
• W2004229999 hasAuthorship W2004229999A5073817755 @default.
• W2004229999 hasAuthorship W2004229999A5078555736 @default.
• W2004229999 hasBestOaLocation W20042299992 @default.
• W2004229999 hasConcept C101762097 @default.
• W2004229999 hasConcept C104317684 @default.
• W2004229999 hasConcept C134018914 @default.
• W2004229999 hasConcept C134320426 @default.
• W2004229999 hasConcept C150194340 @default.
• W2004229999 hasConcept C157880135 @default.
• W2004229999 hasConcept C185592680 @default.
• W2004229999 hasConcept C202751555 @default.
• W2004229999 hasConcept C203014093 @default.
• W2004229999 hasConcept C24998067 @default.
• W2004229999 hasConcept C2776914184 @default.
• W2004229999 hasConcept C2778870864 @default.
• W2004229999 hasConcept C55493867 @default.
• W2004229999 hasConcept C86339819 @default.
• W2004229999 hasConcept C86803240 @default.
• W2004229999 hasConcept C95444343 @default.
• W2004229999 hasConceptScore W2004229999C101762097 @default.

• next